Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging

Hamed Vavadi, Atahar Mostafa, Feifei Zhou, K. M. Shihab Uddin, Murad Althobaiti, Chen Xu, Rajeev Bansal, Foluso Ademuyiwa, Steven Poplack, Quing Zhu

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Near-infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response in patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In this study, we introduce our recently developed ultrasound-guided DOT system, which has been improved in system compactness, robustness, and user-friendliness by custom-designed electronics, automated data preprocessing, and implementation of a new two-step reconstruction algorithm. The system performance has been tested with several sets of solid and blood phantoms and the results show accuracy in reconstructed absorption coefficients as well as blood oxygen saturation. A clinical example of a breast cancer patient, who was undergoing neoadjuvant chemotherapy, is given to demonstrate the system performance.

Original languageEnglish
Article number021203
JournalJournal of biomedical optics
Issue number2
StatePublished - Feb 1 2019


  • diffuse optical tomography
  • imaging reconstruction
  • near-infrared instrument
  • ultrasound


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