TY - JOUR
T1 - Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging
AU - Vavadi, Hamed
AU - Mostafa, Atahar
AU - Zhou, Feifei
AU - Shihab Uddin, K. M.
AU - Althobaiti, Murad
AU - Xu, Chen
AU - Bansal, Rajeev
AU - Ademuyiwa, Foluso
AU - Poplack, Steven
AU - Zhu, Quing
N1 - Publisher Copyright:
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Near-infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response in patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In this study, we introduce our recently developed ultrasound-guided DOT system, which has been improved in system compactness, robustness, and user-friendliness by custom-designed electronics, automated data preprocessing, and implementation of a new two-step reconstruction algorithm. The system performance has been tested with several sets of solid and blood phantoms and the results show accuracy in reconstructed absorption coefficients as well as blood oxygen saturation. A clinical example of a breast cancer patient, who was undergoing neoadjuvant chemotherapy, is given to demonstrate the system performance.
AB - Near-infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response in patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In this study, we introduce our recently developed ultrasound-guided DOT system, which has been improved in system compactness, robustness, and user-friendliness by custom-designed electronics, automated data preprocessing, and implementation of a new two-step reconstruction algorithm. The system performance has been tested with several sets of solid and blood phantoms and the results show accuracy in reconstructed absorption coefficients as well as blood oxygen saturation. A clinical example of a breast cancer patient, who was undergoing neoadjuvant chemotherapy, is given to demonstrate the system performance.
KW - diffuse optical tomography
KW - imaging reconstruction
KW - near-infrared instrument
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85055178130&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.24.2.021203
DO - 10.1117/1.JBO.24.2.021203
M3 - Article
C2 - 30350491
AN - SCOPUS:85055178130
SN - 1083-3668
VL - 24
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 2
M1 - 021203
ER -