Compact, multi-exposure speckle contrast optical spectroscopy (SCOS) device for measuring deep tissue blood flow

Tanja Dragojević, Joseph L. Hollmann, Davide Tamborini, Davide Portaluppi, Mauro Buttafava, Joseph P. Culver, Federica Villa, Turgut Durduran

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Speckle contrast optical spectroscopy (SCOS) measures absolute blood flow in deep tissue, by taking advantage of multi-distance (previously reported in the literature) or multiexposure (reported here) approach. This method promises to use inexpensive detectors to obtain good signal-to-noise ratio, but it has not yet been implemented in a suitable manner for a mass production. Here we present a new, compact, low power consumption, 32 by 2 single photon avalanche diode (SPAD) array that has no readout noise, low dead time and has high sensitivity in low light conditions, such as in vivo measurements. To demonstrate the capability to measure blood flow in deep tissue, healthy volunteers were measured, showing no significant differences from the diffuse correlation spectroscopy. In the future, this array can be miniaturized to a low-cost, robust, battery operated wireless device paving the way for measuring blood flow in a wide-range of applications from sport injury recovery and training to, on-field concussion detection to wearables.

Original languageEnglish
Article number#309436
Pages (from-to)322-334
Number of pages13
JournalBiomedical Optics Express
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2018

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    Dragojević, T., Hollmann, J. L., Tamborini, D., Portaluppi, D., Buttafava, M., Culver, J. P., Villa, F., & Durduran, T. (2018). Compact, multi-exposure speckle contrast optical spectroscopy (SCOS) device for measuring deep tissue blood flow. Biomedical Optics Express, 9(1), 322-334. [#309436]. https://doi.org/10.1364/BOE.9.000322