TY - JOUR
T1 - Compact, multi-exposure speckle contrast optical spectroscopy (SCOS) device for measuring deep tissue blood flow
AU - Dragojević, Tanja
AU - Hollmann, Joseph L.
AU - Tamborini, Davide
AU - Portaluppi, Davide
AU - Buttafava, Mauro
AU - Culver, Joseph P.
AU - Villa, Federica
AU - Durduran, Turgut
N1 - Funding Information:
Fundació CELLEX Barcelona, Ministerio de Economía y Competitividad (PHOTODEMEN-TIA (DPI2015-64358-c1 and c2 (MINECO/FEDER)), Instituto de Salud Carlos III/FEDER (MEDPHOTAGE DTS16/00087), the “Severo Ochoa” Programme for Centres of Excellence in R&D (SEV-2015-0522), the Obra social “la Caixa” Foundation (LlumMedBcn), LASERLAB-EUROPE IV. J.L.Hollmann acknowledges the Marie Curie COFUND (FP7-PEOPLE-2013-COFUND) fellowship.
Publisher Copyright:
© 2017-2018 Optical Society of America.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Speckle contrast optical spectroscopy (SCOS) measures absolute blood flow in deep tissue, by taking advantage of multi-distance (previously reported in the literature) or multiexposure (reported here) approach. This method promises to use inexpensive detectors to obtain good signal-to-noise ratio, but it has not yet been implemented in a suitable manner for a mass production. Here we present a new, compact, low power consumption, 32 by 2 single photon avalanche diode (SPAD) array that has no readout noise, low dead time and has high sensitivity in low light conditions, such as in vivo measurements. To demonstrate the capability to measure blood flow in deep tissue, healthy volunteers were measured, showing no significant differences from the diffuse correlation spectroscopy. In the future, this array can be miniaturized to a low-cost, robust, battery operated wireless device paving the way for measuring blood flow in a wide-range of applications from sport injury recovery and training to, on-field concussion detection to wearables.
AB - Speckle contrast optical spectroscopy (SCOS) measures absolute blood flow in deep tissue, by taking advantage of multi-distance (previously reported in the literature) or multiexposure (reported here) approach. This method promises to use inexpensive detectors to obtain good signal-to-noise ratio, but it has not yet been implemented in a suitable manner for a mass production. Here we present a new, compact, low power consumption, 32 by 2 single photon avalanche diode (SPAD) array that has no readout noise, low dead time and has high sensitivity in low light conditions, such as in vivo measurements. To demonstrate the capability to measure blood flow in deep tissue, healthy volunteers were measured, showing no significant differences from the diffuse correlation spectroscopy. In the future, this array can be miniaturized to a low-cost, robust, battery operated wireless device paving the way for measuring blood flow in a wide-range of applications from sport injury recovery and training to, on-field concussion detection to wearables.
UR - http://www.scopus.com/inward/record.url?scp=85039714587&partnerID=8YFLogxK
U2 - 10.1364/BOE.9.000322
DO - 10.1364/BOE.9.000322
M3 - Article
C2 - 29359106
AN - SCOPUS:85039714587
VL - 9
SP - 322
EP - 334
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 1
M1 - #309436
ER -