Compact and cost-effective lensless telemedicine microscopy for global health applications

Onur Mudanyali, Derek Tseng, Serhan O. Isikman, Cetin Oztoprak, Ikbal Sencan, Waheb Bishara, Oguzhan Yaglidere, Aydogan Ozcan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We demonstrate a telemedicine microscopy platform which operates based on lens free digital holography. It utilizes an incoherent light-source and an opto-electronic sensor-array to record lens free holograms of micro-objects within a sample, which are then rapidly processed using custom-developed algorithms to provide microscopic images of the samples without the use of any lenses, lasers or other bulky optical/mechanical components. This holographic-microscope achieves sub-cellular resolution over a field-of-view of ~24 mm2 which is ∼20 fold larger than a typical 10X objective-lens field-of-view. We implemented this lens free microscopy platform on a compact stand-alone unit (~46 grams with dimensions of ~4.2 x 4.2 x 5.8 cm) as well as on a commercially-available cell-phone which is modified with a light-weight attachment (~38 grams). The imaging performance of these lens free telemedicine-microscopes is demonstrated using several micro-objects including blood cells and water-borne parasites.

Original languageEnglish
Title of host publicationProceedings - 2011 IEEE Global Humanitarian Technology Conference, GHTC 2011
Pages62-65
Number of pages4
DOIs
StatePublished - 2011
Event2011 IEEE Global Humanitarian Technology Conference, GHTC 2011 - Seattle, WA, United States
Duration: Oct 30 2011Nov 1 2011

Publication series

NameProceedings - 2011 IEEE Global Humanitarian Technology Conference, GHTC 2011

Conference

Conference2011 IEEE Global Humanitarian Technology Conference, GHTC 2011
Country/TerritoryUnited States
CitySeattle, WA
Period10/30/1111/1/11

Keywords

  • blood analysis
  • cell-phone microscope
  • digital holography
  • global health
  • holographic microscopy telemedicine
  • in-line holography
  • Lensfree imaging
  • lensfree microscopy
  • LUCAS
  • on-chip imaging
  • waterborne parasites
  • wireless health

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