TY - JOUR
T1 - Communication between chromatin and homologous recombination
AU - Verma, Priyanka
AU - Greenberg, Roger A.
N1 - Funding Information:
RAG is supported by N.I.H. grants GM101149 , CA138835 and CA17494 , the Penn Center for Genome Integrity , the Basser Center for BRCA , a V Foundation Team Convergence Award , and a Gray Foundation Team Science Award . PV was supported by the Ann and Sol Schreiber Mentored Investigator Award (Ovarian Cancer Research Fund Alliance) and Pilot funds from the Ovarian Cancer Translational Center for Excellence (UPenn).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Higher-order chromatin packing serves as a structural barrier to the recognition and repair of genomic lesions. The initiation and outcome of the repair response is dictated by a highly coordinated yet complex interplay between chromatin modifying enzymes and their cognate readers, damage induced chemical modifications, nucleosome density, transcriptional state, and cell cycle-dependent availability of DNA repair machinery. The physical and chemical properties of the DNA lesions themselves further regulate the nature of ensuing chromatin responses. Here we review recent discoveries across these various contexts, where chromatin regulates the homology-guided double-strand break repair mechanism, homologous recombination, and also highlight the key knowledge gaps vital to generate a holistic understanding of this process and its contributions to genome integrity.
AB - Higher-order chromatin packing serves as a structural barrier to the recognition and repair of genomic lesions. The initiation and outcome of the repair response is dictated by a highly coordinated yet complex interplay between chromatin modifying enzymes and their cognate readers, damage induced chemical modifications, nucleosome density, transcriptional state, and cell cycle-dependent availability of DNA repair machinery. The physical and chemical properties of the DNA lesions themselves further regulate the nature of ensuing chromatin responses. Here we review recent discoveries across these various contexts, where chromatin regulates the homology-guided double-strand break repair mechanism, homologous recombination, and also highlight the key knowledge gaps vital to generate a holistic understanding of this process and its contributions to genome integrity.
UR - http://www.scopus.com/inward/record.url?scp=85107272828&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2021.05.006
DO - 10.1016/j.gde.2021.05.006
M3 - Review article
C2 - 34098484
AN - SCOPUS:85107272828
SN - 0959-437X
VL - 71
SP - 1
EP - 9
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -