@article{1db9cce1c9824416ba363388aa7b514d,
title = "Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans",
abstract = "Hair morphology is highly differentiated between populations and among people of European ancestry. Whereas hair morphology in East Asian populations has been studied extensively, relatively little is known about the genetics of this trait in Europeans. We performed a genome-wide association scan for hair morphology (straight, wavy, curly) in three Australian samples of European descent. All three samples showed evidence of association implicating the Trichohyalin gene (TCHH), which is expressed in the developing inner root sheath of the hair follicle, and explaining ∼6% of variance (p = 1.5 × 10-31). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations.",
author = "Medland, {Sarah E.} and Nyholt, {Dale R.} and Painter, {Jodie N.} and McEvoy, {Brian P.} and McRae, {Allan F.} and Gu Zhu and Gordon, {Scott D.} and Ferreira, {Manuel A.R.} and Wright, {Margaret J.} and Henders, {Anjali K.} and Campbell, {Megan J.} and Duffy, {David L.} and Hansell, {Narelle K.} and Stuart Macgregor and Slutske, {Wendy S.} and Heath, {Andrew C.} and Montgomery, {Grant W.} and Martin, {Nicholas G.}",
note = "Funding Information: We thank the twins and their families for their participation. We also thank Dixie Statham, Ann Eldridge, Marlene Grace, Kerrie McAloney (sample collection); Lisa Bowdler, Steven Crooks (DNA processing); David Smyth, Harry Beeby, and Daniel Park (IT support). Funding was provided by the Australian National Health and Medical Research Council (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498), the Australian Research Council (A7960034, A79906588, A79801419, DP0770096, DP0212016, DP0343921), the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254), and the U.S. National Institutes of Health (NIH grants AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206). A portion of the genotyping on which this study was based (Illumina 370K scans on 4300 individuals) was carried out at the Center for Inherited Disease Research, Baltimore (CIDR), through an access award to our late colleague Dr. Richard Todd (Psychiatry, Washington University School of Medicine, St Louis). Statistical analyses were carried out on the Genetic Cluster Computer, which is financially supported by the Netherlands Scientific Organization (NWO 480-05-003). S.E.M., D.R.N., A.F.M., M.A.R.F., S.M., D.L.D., and G.W.M. are supported by the National Health and Medical Research Council (NHMRC) Fellowship Scheme. ",
year = "2009",
month = nov,
day = "13",
doi = "10.1016/j.ajhg.2009.10.009",
language = "English",
volume = "85",
pages = "750--755",
journal = "American journal of human genetics",
issn = "0002-9297",
number = "5",
}