Abstract
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 -9, joint analysis P (P J) = 1.7 × 10 -9; stages 1, 2 and 3, P M = 8.2 × 10 -12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 -9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 -10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 -9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 -10, P J = 5.2 × 10 -11), CLU (rs1532278; P M = 8.3 × 10 -8, P J = 1.9 × 10 -8), BIN1 (rs7561528; P M = 4.0 × 10 -14, P J = 5.2 × 10 -14) and PICALM (rs561655; P M = 7.0 × 10 -11, P J = 1.0 × 10 -10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
Original language | English |
---|---|
Pages (from-to) | 436-443 |
Number of pages | 8 |
Journal | Nature Genetics |
Volume | 43 |
Issue number | 5 |
DOIs | |
State | Published - May 2011 |
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In: Nature Genetics, Vol. 43, No. 5, 05.2011, p. 436-443.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AU - Naj, Adam C.
AU - Jun, Gyungah
AU - Beecham, Gary W.
AU - Wang, Li San
AU - Vardarajan, Badri Narayan
AU - Buros, Jacqueline
AU - Gallins, Paul J.
AU - Buxbaum, Joseph D.
AU - Jarvik, Gail P.
AU - Crane, Paul K.
AU - Larson, Eric B.
AU - Bird, Thomas D.
AU - Boeve, Bradley F.
AU - Graff-Radford, Neill R.
AU - De Jager, Philip L.
AU - Evans, Denis
AU - Schneider, Julie A.
AU - Carrasquillo, Minerva M.
AU - Ertekin-Taner, Nilufer
AU - Younkin, Steven G.
AU - Cruchaga, Carlos
AU - Kauwe, John S.K.
AU - Nowotny, Petra
AU - Kramer, Patricia
AU - Hardy, John
AU - Huentelman, Matthew J.
AU - Myers, Amanda J.
AU - Barmada, Michael M.
AU - Demirci, F. Yesim
AU - Baldwin, Clinton T.
AU - Green, Robert C.
AU - Rogaeva, Ekaterina
AU - George-Hyslop, Peter St
AU - Arnold, Steven E.
AU - Barber, Robert
AU - Beach, Thomas
AU - Bigio, Eileen H.
AU - Bowen, James D.
AU - Boxer, Adam
AU - Burke, James R.
AU - Cairns, Nigel J.
AU - Carlson, Chris S.
AU - Carney, Regina M.
AU - Carroll, Steven L.
AU - Chui, Helena C.
AU - Clark, David G.
AU - Corneveaux, Jason
AU - Cotman, Carl W.
AU - Cummings, Jeffrey L.
AU - Decarli, Charles
AU - Dekosky, Steven T.
AU - Diaz-Arrastia, Ramon
AU - Dick, Malcolm
AU - Dickson, Dennis W.
AU - Ellis, William G.
AU - Faber, Kelley M.
AU - Fallon, Kenneth B.
AU - Farlow, Martin R.
AU - Ferris, Steven
AU - Frosch, Matthew P.
AU - Galasko, Douglas R.
AU - Ganguli, Mary
AU - Gearing, Marla
AU - Geschwind, Daniel H.
AU - Ghetti, Bernardino
AU - Gilbert, John R.
AU - Gilman, Sid
AU - Giordani, Bruno
AU - Glass, Jonathan D.
AU - Growdon, John H.
AU - Hamilton, Ronald L.
AU - Harrell, Lindy E.
AU - Head, Elizabeth
AU - Honig, Lawrence S.
AU - Hulette, Christine M.
AU - Hyman, Bradley T.
AU - Jicha, Gregory A.
AU - Jin, Lee Way
AU - Johnson, Nancy
AU - Karlawish, Jason
AU - Karydas, Anna
AU - Kaye, Jeffrey A.
AU - Kim, Ronald
AU - Koo, Edward H.
AU - Kowall, Neil W.
AU - Lah, James J.
AU - Levey, Allan I.
AU - Lieberman, Andrew P.
AU - Lopez, Oscar L.
AU - MacK, Wendy J.
AU - Marson, Daniel C.
AU - Martiniuk, Frank
AU - Mash, Deborah C.
AU - Masliah, Eliezer
AU - McCormick, Wayne C.
AU - McCurry, Susan M.
AU - McDavid, Andrew N.
AU - McKee, Ann C.
AU - Mesulam, Marsel
AU - Miller, Bruce L.
AU - Miller, Carol A.
AU - Miller, Joshua W.
AU - Parisi, Joseph E.
AU - Perl, Daniel P.
AU - Peskind, Elaine
AU - Petersen, Ronald C.
AU - Poon, Wayne W.
AU - Quinn, Joseph F.
AU - Rajbhandary, Ruchita A.
AU - Raskind, Murray
AU - Reisberg, Barry
AU - Ringman, John M.
AU - Roberson, Erik D.
AU - Rosenberg, Roger N.
AU - Sano, Mary
AU - Schneider, Lon S.
AU - Seeley, William
AU - Shelanski, Michael L.
AU - Slifer, Michael A.
AU - Smith, Charles D.
AU - Sonnen, Joshua A.
AU - Spina, Salvatore
AU - Stern, Robert A.
AU - Tanzi, Rudolph E.
AU - Trojanowski, John Q.
AU - Troncoso, Juan C.
AU - Van Deerlin, Vivianna M.
AU - Vinters, Harry V.
AU - Vonsattel, Jean Paul
AU - Weintraub, Sandra
AU - Welsh-Bohmer, Kathleen A.
AU - Williamson, Jennifer
AU - Woltjer, Randall L.
AU - Cantwell, Laura B.
AU - Dombroski, Beth A.
AU - Beekly, Duane
AU - Lunetta, Kathryn L.
AU - Martin, Eden R.
AU - Kamboh, M. Ilyas
AU - Saykin, Andrew J.
AU - Reiman, Eric M.
AU - Bennett, David A.
AU - Morris, John C.
AU - Montine, Thomas J.
AU - Goate, Alison M.
AU - Blacker, Deborah
AU - Tsuang, Debby W.
AU - Hakonarson, Hakon
AU - Kukull, Walter A.
AU - Foroud, Tatiana M.
AU - Haines, Jonathan L.
AU - Mayeux, Richard
AU - Pericak-Vance, Margaret A.
AU - Farrer, Lindsay A.
AU - Schellenberg, Gerard D.
N1 - Funding Information: The National Institutes of Health, National Institute on Aging (NIH-NIA) supported this work through the following grants: ADGC, U01 AG032984, RC2 AG036528; NACC, U01 AG016976; NCRAD, U24 AG021886; NIA LOAD, U24 AG026395, U24 AG026390; Boston University, P30 AG013846, R01 HG02213, K24 AG027841, U01 AG10483, R01 CA129769, R01 MH080295, R01 AG009029, R01 AG017173, R01 AG025259; Columbia University, P50 AG008702, R37 AG015473; Duke University, P30 AG028377; Emory University, AG025688; Indiana University, P30 AG10133; Johns Hopkins University, P50 AG005146, R01 AG020688; Massachusetts General Hospital, P50 AG005134; Mayo Clinic, P50 AG016574; Mount Sinai School of Medicine, P50 AG005138, P01 AG002219; New York University, P30 AG08051, MO1RR00096, and UL1 RR029893; Northwestern University, P30 AG013854; Oregon Health & Science University, P30 AG008017, R01 AG026916; Rush University, P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, R01 AG30146; University of Alabama at Birmingham, P50 AG016582, UL1RR02777; University of Arizona/TGEN, P30 AG019610, R01 AG031581, R01 NS059873; University of California, Davis, P30 AG010129; University of California, Irvine, P50 AG016573, P50, P50 AG016575, P50 AG016576, P50 AG016577; University of California, Los Angeles, P50 AG016570; University of California, San Diego, P50 AG005131; University of California, San Francisco, P50 AG023501, P01 AG019724; University of Kentucky, P30 AG028383; University of Michigan, P50 AG008671; University of Pennsylvania, P30 AG010124; University of Pittsburgh, P50 AG005133, AG030653; University of Southern California, P50 AG005142; University of Texas Southwestern, P30 AG012300; University of Miami, R01 AG027944, AG010491, AG027944, AG021547, AG019757; University of Washington, P50 AG005136, UO1 AG06781, UO1 HG004610; Vanderbilt University, R01 AG019085; and Washington University, P50 AG005681, P01 AG03991. ADNI Funding for ADNI is through the Northern California Institute for Research and Education by grants from Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc., F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., Alzheimer’s Association, Alzheimer’s Drug Discovery Foundation, the Dana Foundation, and by the National Institute of Biomedical Imaging and Bioengineering and NIA grants U01 AG024904, RC2 AG036535, K01 AG030514. We thank C. Phelps, M. Morrison-Bogorad and M. Miller from NIA who are ex-officio ADGC members. Support was also from the Alzheimer’s Association (LAF, IIRG-08-89720; MP-V, IIRG-05-14147) and the Veterans Affairs Administration. P.S.-H. is supported by Wellcome Trust, Howard Hughes Medical Institute, and the Canadian Institute of Health Research.
PY - 2011/5
Y1 - 2011/5
N2 - The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 -9, joint analysis P (P J) = 1.7 × 10 -9; stages 1, 2 and 3, P M = 8.2 × 10 -12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 -9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 -10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 -9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 -10, P J = 5.2 × 10 -11), CLU (rs1532278; P M = 8.3 × 10 -8, P J = 1.9 × 10 -8), BIN1 (rs7561528; P M = 4.0 × 10 -14, P J = 5.2 × 10 -14) and PICALM (rs561655; P M = 7.0 × 10 -11, P J = 1.0 × 10 -10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
AB - The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 -9, joint analysis P (P J) = 1.7 × 10 -9; stages 1, 2 and 3, P M = 8.2 × 10 -12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 -9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 -10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 -9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 -10, P J = 5.2 × 10 -11), CLU (rs1532278; P M = 8.3 × 10 -8, P J = 1.9 × 10 -8), BIN1 (rs7561528; P M = 4.0 × 10 -14, P J = 5.2 × 10 -14) and PICALM (rs561655; P M = 7.0 × 10 -11, P J = 1.0 × 10 -10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
UR - http://www.scopus.com/inward/record.url?scp=79955464911&partnerID=8YFLogxK
U2 - 10.1038/ng.801
DO - 10.1038/ng.801
M3 - Article
C2 - 21460841
AN - SCOPUS:79955464911
SN - 1061-4036
VL - 43
SP - 436
EP - 443
JO - Nature Genetics
JF - Nature Genetics
IS - 5
ER -