Common genetic vulnerability for nicotine and alcohol dependence in men

William R. True, Hong Xian, Jeffrey F. Scherrer, Pamela A.F. Madden, Kathleen K. Bucholz, Andrew C. Heath, Seth A. Eisen, Michael J. Lyons, Jack Goldberg, Ming Tsuang

Research output: Contribution to journalArticlepeer-review

398 Scopus citations

Abstract

Background: Nicotine and alcohol dependence often occur together. We examined data from male twin pairs to determine whether there are genetic or environmental influences common to nicotine and alcohol dependence, and, if so, to estimate the magnitude and correlation of these influences. Methods: Subjects were 3356 male-male twin-pair members of the Vietnam Era Twin Registry who participated in a 1992 telephone administration of the Diagnostic Interview Schedule Version 3 Revised. Genetic model fitting was performed to estimate the magnitude and correlation of genetic and environmental contributions to lifetime nicotine and alcohol dependence. Results: The heritability of nicotine dependence was 60.3% (95% confidence interval [CI], 55.4%-65.2%); that of alcohol dependence, 55.1% (95% CI, 49.7%-60.5%). The best-fitting model for the co-occurrence of lifetime nicotine and alcohol dependence included a substantial genetic correlation between both disorders (r = 0.68; 95% CI, 0.61-0.74) and a modest unique environmental correlation (r = 0.23; 95% CI, 0.14-032). Conclusions: These data suggest a common genetic vulnerability to nicotine and alcohol dependence in men. This common genetic influence may partially explain the clinical and epidemiological observations that alcoholics are often dependent smokers.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalArchives of General Psychiatry
Volume56
Issue number7
DOIs
StatePublished - Jul 1999

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