Common genetic risk factors for conduct disorder and alcohol dependence

Wendy S. Slutske, Andrew C. Heath, Stephen H. Dinwiddie, Pamela A.F. Madden, Kathleen K. Bucholz, Michael P. Dunne, Dixie J. Statham, Nicholas G. Martin

Research output: Contribution to journalArticlepeer-review

239 Scopus citations

Abstract

The association between retrospectively reported childhood conduct disorder (CD) and a history of alcohol dependence (AD) was examined in a sample of 2,682 male, female, and unlike-sex adult twin pairs. There was a strong association between CD and AD in both men (tetrachoric r = .34, odds ratio = 2.8) and women (tetrachoric r = .53, odds ratio = 9.9). Genetic factors accounted for most of the association between CD and AD liability in men and women, with the remainder of the association being due to nonshared individual-specific environmental factors. Genetic influences common to CD and AD accounted for 17% and 35% of the genetic variation in AD liability in men and women, respectively, and accounted for 11% and 23% of the total variation in AD liability in men and women, respectively. The results suggest that there are common genetic risk factors for CD and AD or that CD itself is an important genetically influenced risk factor for AD.

Original languageEnglish
Pages (from-to)363-374
Number of pages12
JournalJournal of Abnormal Psychology
Volume107
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Dive into the research topics of 'Common genetic risk factors for conduct disorder and alcohol dependence'. Together they form a unique fingerprint.

Cite this