TY - JOUR
T1 - Common genetic risk factors for conduct disorder and alcohol dependence
AU - Slutske, Wendy S.
AU - Heath, Andrew C.
AU - Dinwiddie, Stephen H.
AU - Madden, Pamela A.F.
AU - Bucholz, Kathleen K.
AU - Dunne, Michael P.
AU - Statham, Dixie J.
AU - Martin, Nicholas G.
PY - 1998
Y1 - 1998
N2 - The association between retrospectively reported childhood conduct disorder (CD) and a history of alcohol dependence (AD) was examined in a sample of 2,682 male, female, and unlike-sex adult twin pairs. There was a strong association between CD and AD in both men (tetrachoric r = .34, odds ratio = 2.8) and women (tetrachoric r = .53, odds ratio = 9.9). Genetic factors accounted for most of the association between CD and AD liability in men and women, with the remainder of the association being due to nonshared individual-specific environmental factors. Genetic influences common to CD and AD accounted for 17% and 35% of the genetic variation in AD liability in men and women, respectively, and accounted for 11% and 23% of the total variation in AD liability in men and women, respectively. The results suggest that there are common genetic risk factors for CD and AD or that CD itself is an important genetically influenced risk factor for AD.
AB - The association between retrospectively reported childhood conduct disorder (CD) and a history of alcohol dependence (AD) was examined in a sample of 2,682 male, female, and unlike-sex adult twin pairs. There was a strong association between CD and AD in both men (tetrachoric r = .34, odds ratio = 2.8) and women (tetrachoric r = .53, odds ratio = 9.9). Genetic factors accounted for most of the association between CD and AD liability in men and women, with the remainder of the association being due to nonshared individual-specific environmental factors. Genetic influences common to CD and AD accounted for 17% and 35% of the genetic variation in AD liability in men and women, respectively, and accounted for 11% and 23% of the total variation in AD liability in men and women, respectively. The results suggest that there are common genetic risk factors for CD and AD or that CD itself is an important genetically influenced risk factor for AD.
UR - http://www.scopus.com/inward/record.url?scp=0031872462&partnerID=8YFLogxK
U2 - 10.1037/0021-843X.107.3.363
DO - 10.1037/0021-843X.107.3.363
M3 - Article
C2 - 9715572
AN - SCOPUS:0031872462
SN - 0021-843X
VL - 107
SP - 363
EP - 374
JO - Journal of Abnormal Psychology
JF - Journal of Abnormal Psychology
IS - 3
ER -