Commissioning and initial experience with the first clinical gantry-mounted proton therapy system

Tianyu Zhao, Baozhou Sun, Kevin Grantham, Leith Rankine, Bin Cai, Sreekrishna M. Goddu, Lakshmi Santanam, Nels Knutson, Tiezhi Zhang, Michael Reilly, Beth Bottani, Jeffrey Bradley, Sasa Mutic, Eric E. Klein

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The purpose of this study is to describe the comprehensive commissioning process and initial clinical experience of the Mevion S250 proton therapy system, a gantry-mounted, single-room proton therapy platform clinically implemented in the S. Lee Kling Proton Therapy Center at Barnes-Jewish Hospital in St. Louis, MO, USA. The Mevion S250 system integrates a compact synchrocyclotron with a C-inner gantry, an image guidance system and a 6D robotic couch into a beam delivery platform. We present our commissioning process and initial clinical experience, including i) CT calibration; ii) beam data acquisition and machine characteristics; iii) dosimetric commissioning of the treatment planning system; iv) validation through the Imaging and Radiation Oncology Core credentialing process, including irradiations on the spine, prostate, brain, and lung phantoms; v) evaluation of localization accuracy of the image guidance system; and vi) initial clinical experience. Clinically, the system operates well and has provided an excellent platform for the treatment of diseases with protons.

Original languageEnglish
Pages (from-to)24-40
Number of pages17
JournalJournal of applied clinical medical physics
Issue number2
StatePublished - 2016


  • Commissioning
  • Passive scattering
  • Proton


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