Comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

Original languageEnglish
Pages (from-to)405a
JournalScience
Volume333
Issue number6041
DOIs
StatePublished - Jul 22 2011

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