Comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"

Kenneth M. Murphy

doi:10.1126/science.1198277

Comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"

Kenneth M. Murphy

Research output: Contribution to journal › Comment/debate

11 Scopus citations

Abstract

Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

Original language	English
Pages (from-to)	405a
Journal	Science
Volume	333
Issue number	6041
DOIs	https://doi.org/10.1126/science.1198277
State	Published - Jul 22 2011

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abstract = "Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.",

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AB - Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

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Comment on "activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine"

Abstract

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