Combining immunotherapy with radiation therapy in thoracic oncology

Shahed N. Badiyan, Michael C. Roach, Michael D. Chuong, Stephanie R. Rice, Nasarachi E. Onyeuku, Jill Remick, Srinivas Chilukuri, Erica Glass, Pranshu Mohindra, Charles B. Simone

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Thoracic malignancies comprise some of the most common and deadly cancers. Immunotherapies have been proven to improve survival outcomes for patients with advanced nonsmall cell lung cancer (NSCLC) and show great potential for patients with other thoracic malignancies. Radiation therapy (RT), an established and effective treatment for thoracic cancers, has acted synergistically with immunotherapies in preclinical studies. Ongoing clinical trials are exploring the clinical benefits of combining RT with immunotherapies and the optimal manner in which to deliver these complementary treatments.

Original languageEnglish
Pages (from-to)S2492-S2507
JournalJournal of Thoracic Disease
Volume10
DOIs
StatePublished - Aug 1 2018

Keywords

  • Esophageal cancer
  • Immune checkpoint inhibitors (ICIs)
  • Immunotherapy
  • Lung cancer
  • Mesothelioma
  • Radiation therapy (RT)
  • Thymoma

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  • Cite this

    Badiyan, S. N., Roach, M. C., Chuong, M. D., Rice, S. R., Onyeuku, N. E., Remick, J., Chilukuri, S., Glass, E., Mohindra, P., & Simone, C. B. (2018). Combining immunotherapy with radiation therapy in thoracic oncology. Journal of Thoracic Disease, 10, S2492-S2507. https://doi.org/10.21037/jtd.2018.05.73