Combined solution-phase and solid-phase synthesis of 2-amino-7,8-dihydropteridin-6(5H)-ones

Axel Metzger, Lan Ying Qin, Andrew G. Cole, Kurt W. Saionz, Marc Raleigh Brescia, Hubert Gstach, James R. Wareing, Juerg Zimmermann, Wolfgang K.D. Brill, John J. Baldwin, Roland E. Dolle, Ian Henderson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


An efficient and general synthesis of substituted 2-amino-7,8-dihydropteridin-6(5H)-ones using a combination of solution-phase and solid-phase chemistry is described. Solution-phase chemistry was used to produce two pyrimidine regioisomers that were separated by flash column chromatography. Utilizing the desired regioisomer, solid-phase chemistry was used to effect the rapid construction of the substituted 2-amino-7,8-dihydropteridin-6(5H)-one system in high overall yield and purity.

Original languageEnglish
Pages (from-to)7082-7085
Number of pages4
JournalTetrahedron Letters
Issue number50
StatePublished - Dec 16 2009


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