Combined radiosensitization and radioprotection for oral cavity tumors: Study with an oral cavity tumor model

Perry Grigsby; Yosh Maruyama

doi:10.1016/0360-3016(82)90683-6

Combined radiosensitization and radioprotection for oral cavity tumors: Study with an oral cavity tumor model

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Abstract

Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.

Original language	English
Pages (from-to)	557-559
Number of pages	3
Journal	International journal of radiation oncology, biology, physics
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1016/0360-3016(82)90683-6
State	Published - 1982

Keywords

Combined protection-sensitization
EMT 6
Oral tumor model
Radioprotectors
Radiosensitizers

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10.1016/0360-3016(82)90683-6

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title = "Combined radiosensitization and radioprotection for oral cavity tumors: Study with an oral cavity tumor model",

abstract = "Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.",

keywords = "Combined protection-sensitization, EMT 6, Oral tumor model, Radioprotectors, Radiosensitizers",

author = "Perry Grigsby and Yosh Maruyama",

note = "Funding Information: Presented at the Conference on Chemical Modification: Radiation and Cytotoxic Drugs, Key Biscayne, Florida, September 16,20,198l. Supported in part by research grant from the National Cancer Institute Rdl CA 13849, PO1 CA 17786. Reprint requests to: Perry W. Grigsby, M.S.",

year = "1982",

doi = "10.1016/0360-3016(82)90683-6",

language = "English",

volume = "8",

pages = "557--559",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

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T1 - Combined radiosensitization and radioprotection for oral cavity tumors

T2 - Study with an oral cavity tumor model

AU - Grigsby, Perry

AU - Maruyama, Yosh

N1 - Funding Information: Presented at the Conference on Chemical Modification: Radiation and Cytotoxic Drugs, Key Biscayne, Florida, September 16,20,198l. Supported in part by research grant from the National Cancer Institute Rdl CA 13849, PO1 CA 17786. Reprint requests to: Perry W. Grigsby, M.S.

PY - 1982

Y1 - 1982

N2 - Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.

AB - Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.

KW - Combined protection-sensitization

KW - EMT 6

KW - Oral tumor model

KW - Radioprotectors

KW - Radiosensitizers

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IS - 3-4

ER -

Combined radiosensitization and radioprotection for oral cavity tumors: Study with an oral cavity tumor model

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Keywords

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