TY - JOUR
T1 - Combined radiosensitization and radioprotection for oral cavity tumors
T2 - Study with an oral cavity tumor model
AU - Grigsby, Perry
AU - Maruyama, Yosh
N1 - Funding Information:
Presented at the Conference on Chemical Modification: Radiation and Cytotoxic Drugs, Key Biscayne, Florida, September 16,20,198l. Supported in part by research grant from the National Cancer Institute Rdl CA 13849, PO1 CA 17786. Reprint requests to: Perry W. Grigsby, M.S.
PY - 1982
Y1 - 1982
N2 - Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.
AB - Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.
KW - Combined protection-sensitization
KW - EMT 6
KW - Oral tumor model
KW - Radioprotectors
KW - Radiosensitizers
UR - http://www.scopus.com/inward/record.url?scp=0019977998&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(82)90683-6
DO - 10.1016/0360-3016(82)90683-6
M3 - Article
C2 - 6286553
AN - SCOPUS:0019977998
SN - 0360-3016
VL - 8
SP - 557
EP - 559
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 3-4
ER -