Combined radiosensitization and radioprotection for oral cavity tumors: Study with an oral cavity tumor model

Perry Grigsby, Yosh Maruyama

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Adjuvant therapy with combined radioprotectors and radiosensitizers has not been extensively examined. We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice. Our results demonstrate that single dose irradiation plus WR-2721 or misonidazole prolonged the mean survival time (MST) of EMT 6/Ky bearing Balb/c mice significantly compared to either controls or single dose irradiation plus WR-2721 and misonidazole.

Original languageEnglish
Pages (from-to)557-559
Number of pages3
JournalInternational journal of radiation oncology, biology, physics
Volume8
Issue number3-4
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Keywords

  • Combined protection-sensitization
  • EMT 6
  • Oral tumor model
  • Radioprotectors
  • Radiosensitizers

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