Combined optically coupled transmembrane potential and transmembrane current recording arrays

Francis X. Witkowski; Patrica A. Penkoske; Katherine M. Kavanagh

Combined optically coupled transmembrane potential and transmembrane current recording arrays

Francis X. Witkowski, Patrica A. Penkoske, Katherine M. Kavanagh

Division of Critical Care

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The spatial and temporal complexity of activation and repolarization sequences observed during ventricular arrhythmias such as ventricular fibrillation have hampered their mechanistic elucidation. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. We have combined this extracellular electrogram recording array with an immediately adjacent fiber optically coupled transmembrane potential recording array. Using these arrays in isolated blood perfused dog hearts the kinetics of both activation and repolarization can, be recorded without the need for cell disruption.

Original language	English
Title of host publication	Proceedings of the Annual Conference on Engineering in Medicine and Biology
Editors	Andrew Y.J. Szeto, Rangaraj M. Rangayyan
Publisher	Publ by IEEE
Pages	863-864
Number of pages	2
Edition	pt 2
ISBN (Print)	0780313771
State	Published - Dec 1 1993
Event	Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3) - San Diego, CA, USA Duration: Oct 28 1993 → Oct 31 1993

Publication series

Name	Proceedings of the Annual Conference on Engineering in Medicine and Biology
Number	pt 2
Volume	15
ISSN (Print)	0589-1019

Conference

Conference	Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3)
City	San Diego, CA, USA
Period	10/28/93 → 10/31/93

Cite this

Witkowski, F. X., Penkoske, P. A., & Kavanagh, K. M. (1993). Combined optically coupled transmembrane potential and transmembrane current recording arrays. In A. Y. J. Szeto, & R. M. Rangayyan (Eds.), Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., pp. 863-864). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; Vol. 15, No. pt 2). Publ by IEEE.

Witkowski, Francis X. ; Penkoske, Patrica A. ; Kavanagh, Katherine M. / Combined optically coupled transmembrane potential and transmembrane current recording arrays. Proceedings of the Annual Conference on Engineering in Medicine and Biology. editor / Andrew Y.J. Szeto ; Rangaraj M. Rangayyan. pt 2. ed. Publ by IEEE, 1993. pp. 863-864 (Proceedings of the Annual Conference on Engineering in Medicine and Biology; pt 2).

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title = "Combined optically coupled transmembrane potential and transmembrane current recording arrays",

abstract = "The spatial and temporal complexity of activation and repolarization sequences observed during ventricular arrhythmias such as ventricular fibrillation have hampered their mechanistic elucidation. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. We have combined this extracellular electrogram recording array with an immediately adjacent fiber optically coupled transmembrane potential recording array. Using these arrays in isolated blood perfused dog hearts the kinetics of both activation and repolarization can, be recorded without the need for cell disruption.",

author = "Witkowski, {Francis X.} and Penkoske, {Patrica A.} and Kavanagh, {Katherine M.}",

year = "1993",

month = dec,

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series = "Proceedings of the Annual Conference on Engineering in Medicine and Biology",

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booktitle = "Proceedings of the Annual Conference on Engineering in Medicine and Biology",

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note = "Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3) ; Conference date: 28-10-1993 Through 31-10-1993",

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Witkowski, FX, Penkoske, PA & Kavanagh, KM 1993, Combined optically coupled transmembrane potential and transmembrane current recording arrays. in AYJ Szeto & RM Rangayyan (eds), Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 edn, Proceedings of the Annual Conference on Engineering in Medicine and Biology, no. pt 2, vol. 15, Publ by IEEE, pp. 863-864, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3), San Diego, CA, USA, 10/28/93.

Combined optically coupled transmembrane potential and transmembrane current recording arrays. / Witkowski, Francis X.; Penkoske, Patrica A.; Kavanagh, Katherine M.
Proceedings of the Annual Conference on Engineering in Medicine and Biology. ed. / Andrew Y.J. Szeto; Rangaraj M. Rangayyan. pt 2. ed. Publ by IEEE, 1993. p. 863-864 (Proceedings of the Annual Conference on Engineering in Medicine and Biology; Vol. 15, No. pt 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Combined optically coupled transmembrane potential and transmembrane current recording arrays

AU - Witkowski, Francis X.

AU - Penkoske, Patrica A.

AU - Kavanagh, Katherine M.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - The spatial and temporal complexity of activation and repolarization sequences observed during ventricular arrhythmias such as ventricular fibrillation have hampered their mechanistic elucidation. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. We have combined this extracellular electrogram recording array with an immediately adjacent fiber optically coupled transmembrane potential recording array. Using these arrays in isolated blood perfused dog hearts the kinetics of both activation and repolarization can, be recorded without the need for cell disruption.

AB - The spatial and temporal complexity of activation and repolarization sequences observed during ventricular arrhythmias such as ventricular fibrillation have hampered their mechanistic elucidation. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. We have combined this extracellular electrogram recording array with an immediately adjacent fiber optically coupled transmembrane potential recording array. Using these arrays in isolated blood perfused dog hearts the kinetics of both activation and repolarization can, be recorded without the need for cell disruption.

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M3 - Conference contribution

AN - SCOPUS:0027840335

SN - 0780313771

T3 - Proceedings of the Annual Conference on Engineering in Medicine and Biology

SP - 863

EP - 864

BT - Proceedings of the Annual Conference on Engineering in Medicine and Biology

A2 - Szeto, Andrew Y.J.

A2 - Rangayyan, Rangaraj M.

PB - Publ by IEEE

T2 - Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3)

Y2 - 28 October 1993 through 31 October 1993

ER -

Witkowski FX, Penkoske PA, Kavanagh KM. Combined optically coupled transmembrane potential and transmembrane current recording arrays. In Szeto AYJ, Rangayyan RM, editors, Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 ed. Publ by IEEE. 1993. p. 863-864. (Proceedings of the Annual Conference on Engineering in Medicine and Biology; pt 2).

Combined optically coupled transmembrane potential and transmembrane current recording arrays

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