@inproceedings{2ac22fd679c249cbbfd94ee5ae2dd91b,
title = "Combined optical and mechanical scanning in optical-resolution photoacoustic microscopy",
abstract = "Combined optical and mechanical scanning (COMS) in optical-resolution photoacoustic microscopy (OR-PAM) has provided five scanning modes with fast imaging speed and wide field of view (FOV). With two-dimensional (2D) galvanometer-based optical scanning, we have achieved a 2 KHz B-scan rate and 50 Hz volumetric-scan rate, which enables real-time tracking of cell activities in vivo. With optical-mechanical hybrid 2D scanning, we are able to image a wide FOV (10×8 mm2) within 150 seconds, which is 20 times faster than the conventional mechanical scan in our second-generation OR-PAM. With three-dimensional mechanical-based contour scanning, we can maintain the optimal signal-to-noise ratio and spatial resolution of OR-PAM while imaging objects with uneven surfaces, which is ideal for fast and quantitative studies of tumors and the brain.",
keywords = "Medical and biological imaging, Photoacoustic imaging, Scanning microscopy, Three-dimensional microscopy",
author = "Lei Li and Chenghung Yeh and Song Hu and Lidai Wang and Soetikno, \{Brian T.\} and Ruimin Chen and Qifa Zhou and Shung, \{K. Kirk\} and Maslov, \{Konstantin I.\} and Wang, \{Lihong V.\}",
year = "2014",
doi = "10.1117/12.2038693",
language = "English",
isbn = "9780819498564",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2014 ; Conference date: 02-02-2014 Through 05-02-2014",
}