TY - JOUR
T1 - Combined Heart-Kidney Transplantation
T2 - The University of Wisconsin Experience
AU - Hermsen, Joshua L.
AU - Nath, Dilip S.
AU - Munoz del Rio, Alejandro
AU - Eickstaedt, Joshua B.
AU - Wigfield, Christopher
AU - Lindsey, Joshua D.
AU - Edwards, Niloo M.
PY - 2007/11
Y1 - 2007/11
N2 - Background: Combined heart-kidney transplantation (HKTx) is increasing in frequency, but long-term outcomes are unknown and appropriately comparative analysis is lacking. Methods: This study was a retrospective review of prospectively collected data for 19 HKTx patients. Patient and graft survival, graft rejection and coronary allograft vasculopathy (CAV) were compared for HKTx vs recipients of a heart (n = 515) or kidney alone (n = 3,188) or both organs at separate time-points (n = 8). Results: Patient and graft survival did not differ for HKTx vs any group. HKTx time to first rejection episode was significantly prolonged for both organs vs single-organ recipients. The incidence of CAV was significantly lower for HKTx. Conclusions: HKTx provides outcomes similar to those for solitary heart or kidney transplantation. There may be an immunologic advantage to receiving organs in a combined fashion. Such allocation of organs seems medically appropriate; however, more refined strategies are needed to identify optimal recipient populations.
AB - Background: Combined heart-kidney transplantation (HKTx) is increasing in frequency, but long-term outcomes are unknown and appropriately comparative analysis is lacking. Methods: This study was a retrospective review of prospectively collected data for 19 HKTx patients. Patient and graft survival, graft rejection and coronary allograft vasculopathy (CAV) were compared for HKTx vs recipients of a heart (n = 515) or kidney alone (n = 3,188) or both organs at separate time-points (n = 8). Results: Patient and graft survival did not differ for HKTx vs any group. HKTx time to first rejection episode was significantly prolonged for both organs vs single-organ recipients. The incidence of CAV was significantly lower for HKTx. Conclusions: HKTx provides outcomes similar to those for solitary heart or kidney transplantation. There may be an immunologic advantage to receiving organs in a combined fashion. Such allocation of organs seems medically appropriate; however, more refined strategies are needed to identify optimal recipient populations.
UR - http://www.scopus.com/inward/record.url?scp=36048934299&partnerID=8YFLogxK
U2 - 10.1016/j.healun.2007.08.011
DO - 10.1016/j.healun.2007.08.011
M3 - Article
C2 - 18022077
AN - SCOPUS:36048934299
SN - 1053-2498
VL - 26
SP - 1119
EP - 1126
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
IS - 11
ER -