Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth

Keyphrases

• Protein Kinase 100%
• Gene Deletion 100%
• Heart Growth 100%
• GC Gene 100%
• Cardiomyocyte Proteins 100%
• Novel PKC 23%
• Signaling Pathway 15%
• Protein Kinase C Isoforms 15%
• Single Deletion 15%
• Periostin (POSTN) 15%
• Atypical PKC 15%
• Gene Expression Analysis 7%
• Growth Inhibition 7%
• Cell Growth 7%
• Stress-activated Protein Kinase 7%
• Growth Signaling 7%
• Cardiac Stress 7%
• Cardiac Development 7%
• In Cancer 7%
• Hyperplasia 7%
• Ubiquitous Proteins 7%
• Ablation 7%
• Extracellular Signal-regulated Kinase 7%
• Genetic Ablation 7%
• Cardiac Hypertrophy 7%
• Changes in Gene Expression 7%
• Transcriptional Repression 7%
• Cardiomyocytes 7%
• Therapeutic Inhibitors 7%
• Transcriptional Changes 7%
• Environmental Cues 7%
• Feedback Inhibition 7%
• Cardiac Genes 7%
• Cardiac Dysfunction 7%
• Developmental Cues 7%
• Enhanced Growth 7%
• Stress Adaptation 7%
• Functional Overlap 7%
• Germline Deletion 7%
• Early Lethality 7%
• Direct Growth 7%
• Novel Protein Kinase C 7%
• Suppressing Effect 7%
• Pathological Hypertrophy 7%
• Isoform Protein 7%
• Physiological Action 7%

Biochemistry, Genetics and Molecular Biology

• Gene Deletion 100%
• Protein Kinase C 100%
• Cardiac Muscle Cell 100%
• Isoform 13%
• Periostin 13%
• Germline 6%
• Germ Cell 6%
• Enzyme 6%
• Gene Expression 6%
• Cell Growth 6%
• Kinase 6%
• Gene Expression Profiling 6%
• C-Jun N-Terminal Kinases 6%
• Genetic Ablation 6%
• Product Inhibition 6%
• Hemodynamic 6%
• Derepression 6%
• Extracellular Signal-Regulated Kinases 6%