TY - GEN
T1 - Combinatorial model for sequence and spatial motif discovery in short sequence fragments
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
AU - Jackups, Ronald
AU - Liang, Jie
PY - 2006
Y1 - 2006
N2 - Motifs are over-represented sequence or spatial patterns appearing in proteins. They often play important roles in maintaining protein stability and in facilitating protein functions. When motifs are located in short sequence fragments, as in transmembrane domains that are only 10-20 residues in length, and when there is only very limited data, it is difficult to identify motifs. In this study, we develop combinatorial models for assessing statistically significant sequence and spatial patterns. We show our method can uncover previously unknown sequence and spatial motifs in β-barrel membrane proteins.
AB - Motifs are over-represented sequence or spatial patterns appearing in proteins. They often play important roles in maintaining protein stability and in facilitating protein functions. When motifs are located in short sequence fragments, as in transmembrane domains that are only 10-20 residues in length, and when there is only very limited data, it is difficult to identify motifs. In this study, we develop combinatorial models for assessing statistically significant sequence and spatial patterns. We show our method can uncover previously unknown sequence and spatial motifs in β-barrel membrane proteins.
UR - http://www.scopus.com/inward/record.url?scp=34047173649&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.259727
DO - 10.1109/IEMBS.2006.259727
M3 - Conference contribution
C2 - 17947032
AN - SCOPUS:34047173649
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 3470
EP - 3473
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -