TY - JOUR
T1 - Combinatorial assembly of neurons
T2 - from chromatin to dendrites
AU - de la Torre-Ubieta, Luis
AU - Bonni, Azad
N1 - Funding Information:
We thank members of the Bonni laboratory for critical reading of the manuscript. This work is supported by NIH grants to A.B. (NS41021 and NS051255) and a predoctoral fellowship from the National Science Foundation to L.T.U. We apologize to our colleagues whose work was not cited owing to space limitations.
PY - 2008/2
Y1 - 2008/2
N2 - The generation and refinement of dendrites is essential for normal brain development and function. However, the molecular mechanisms that govern dendritic morphogenesis are poorly understood. Recent studies from the Crabtree laboratory have uncovered a requirement for the neuron-specific chromatin-remodeling enzyme nBAF in dendritic growth and branching in response to neuronal activity. These findings highlight the significance of epigenetic mechanisms in activity-dependent dendritic morphogenesis, with important implications in brain development and plasticity.
AB - The generation and refinement of dendrites is essential for normal brain development and function. However, the molecular mechanisms that govern dendritic morphogenesis are poorly understood. Recent studies from the Crabtree laboratory have uncovered a requirement for the neuron-specific chromatin-remodeling enzyme nBAF in dendritic growth and branching in response to neuronal activity. These findings highlight the significance of epigenetic mechanisms in activity-dependent dendritic morphogenesis, with important implications in brain development and plasticity.
UR - http://www.scopus.com/inward/record.url?scp=39149142195&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2007.12.003
DO - 10.1016/j.tcb.2007.12.003
M3 - Short survey
C2 - 18222691
AN - SCOPUS:39149142195
SN - 0962-8924
VL - 18
SP - 48
EP - 51
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -