Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy

Nicholas M. Bontumasi; David Sheinbein; Eva A. Hurst

Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy

Nicholas M. Bontumasi, David Sheinbein, Eva A. Hurst

Division of Dermatology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Perianal squamous cell carcinoma in situ (SCCIS) is a relatively rare intraepidermal neoplasm that has the potential to progress to invasive squamous cell carcinoma. First-line treatment is surgical excision, though nonsurgical treatment modalities such as 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and imiquimod also have been investigated for this neoplasm. Unfortunately, recurrences are known to occur after both surgical and nonsurgical monotherapies. We report a case of perianal SCCIS that was successfully treated with a novel combination of ALA-PDT and imiquimod.

Original language	English
Pages (from-to)	252-254
Number of pages	3
Journal	Cutis
Volume	94
Issue number	5
State	Published - Jan 1 2014

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title = "Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy",

abstract = "Perianal squamous cell carcinoma in situ (SCCIS) is a relatively rare intraepidermal neoplasm that has the potential to progress to invasive squamous cell carcinoma. First-line treatment is surgical excision, though nonsurgical treatment modalities such as 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and imiquimod also have been investigated for this neoplasm. Unfortunately, recurrences are known to occur after both surgical and nonsurgical monotherapies. We report a case of perianal SCCIS that was successfully treated with a novel combination of ALA-PDT and imiquimod.",

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T1 - Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy

AU - Bontumasi, Nicholas M.

AU - Sheinbein, David

AU - Hurst, Eva A.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Perianal squamous cell carcinoma in situ (SCCIS) is a relatively rare intraepidermal neoplasm that has the potential to progress to invasive squamous cell carcinoma. First-line treatment is surgical excision, though nonsurgical treatment modalities such as 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and imiquimod also have been investigated for this neoplasm. Unfortunately, recurrences are known to occur after both surgical and nonsurgical monotherapies. We report a case of perianal SCCIS that was successfully treated with a novel combination of ALA-PDT and imiquimod.

AB - Perianal squamous cell carcinoma in situ (SCCIS) is a relatively rare intraepidermal neoplasm that has the potential to progress to invasive squamous cell carcinoma. First-line treatment is surgical excision, though nonsurgical treatment modalities such as 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and imiquimod also have been investigated for this neoplasm. Unfortunately, recurrences are known to occur after both surgical and nonsurgical monotherapies. We report a case of perianal SCCIS that was successfully treated with a novel combination of ALA-PDT and imiquimod.

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M3 - Article

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VL - 94

SP - 252

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JO - Cutis

JF - Cutis

SN - 0011-4162

IS - 5

ER -

Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy

Abstract

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