TY - JOUR
T1 - Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters
AU - Aslam, Saima
AU - Trautner, Barbara W.
AU - Ramanathan, Venkat
AU - Darouiche, Rabih O.
PY - 2007/4
Y1 - 2007/4
N2 - To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine- tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
AB - To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine- tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
UR - https://www.scopus.com/pages/publications/34247103735
U2 - 10.1128/AAC.00893-06
DO - 10.1128/AAC.00893-06
M3 - Article
C2 - 17220399
AN - SCOPUS:34247103735
SN - 0066-4804
VL - 51
SP - 1556
EP - 1558
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
ER -