Combination ivermectin plus diethylcarbamazine, a new effective tool for control of lymphatic filariasis

J. P. Moulia-Pelat, Ph Glaziou, G. J. Weil, L. N. Nguyen, Ph Gaxotte, L. Nicolas

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

In 1993, a three arm double-blind controlled trial was implemented in French Polynesia, to compare the tolerance and efficacy of single doses of the combination ivermectin (IVR) 400μg.kg-1 plus diethylcarbamazine (DEC) 6 mg.kg-1 vs. IVR 400μg.kg-1 or DEC 6mg.kg-1 alone, for treatment of Wuchereria bancrofti carriers. Of the 57 treated male patients in whom microfilaremia (mf) densities ranged from 22 to 4,709 mf/ml, three groups of 19 were randomly selected, and allocated to one of the three treatments. Twelve months after treatment 37%, 16% and 16% of patients were mf negative in groups DEC, IVR and IVR plus DEC respectively. Mf percent return to pretreatment level was significantly lower in the group IVR + DEC (1.9%) than for DEC 6 (14.7%) or IVR 400 (11.6%). Antigenemia percent return to pretreatment level was lower in the groups IVR + DEC or DEC 6 than for IVR 400. The combination IVR + DEC proved to be the most effective on macrofilariae and microfilariae (antigenemia and mf negative patients). The combination will be a very powerful tool for control of lymphatic filariasis. An annual filariasis day could be the most cost-effective strategy for administration of the drugs.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalTropical Medicine and Parasitology
Volume46
Issue number1
StatePublished - Jan 1 1995
Externally publishedYes

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    Moulia-Pelat, J. P., Glaziou, P., Weil, G. J., Nguyen, L. N., Gaxotte, P., & Nicolas, L. (1995). Combination ivermectin plus diethylcarbamazine, a new effective tool for control of lymphatic filariasis. Tropical Medicine and Parasitology, 46(1), 9-12.