Combination antiretroviral therapy modulates the blood oxygen level-dependent amplitude in human immunodeficiency virus-seropositive patients

Beau M. Ances, Anne C. Roc, Marc Korczykowski, Ronald L. Wolf, Dennis L. Kolson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Combination antiretroviral therapy (cART) limits human immunodeficiency virus (HIV) replication in the central nervous system (CNS) and prevents progressive neurological dysfunction. We examined if the degree of CNS penetration by cART, as estimated by the CNS penetration effectiveness (CPE) score, affects brain activity as measured by the amplitude of the blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) response. HIV+ patients on low-CPE cART (n=12) had a significantly greater BOLD fMRI response amplitude than HIV+ patients on high-CPE cART (n=12) or seronegative controls (n=10). An increase in the BOLD fMRI response in HIV patients on low-CPE cART may reflect continued HIV replication in the CNS leading to increased oxidative stress and associated metabolic demands.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalJournal of NeuroVirology
Volume14
Issue number5
DOIs
StatePublished - 2008

Keywords

  • Combination antiretroviral therapy (cART)
  • Functional magnetic resonance imaging
  • HIV-associated neurocognitive disorders

Fingerprint

Dive into the research topics of 'Combination antiretroviral therapy modulates the blood oxygen level-dependent amplitude in human immunodeficiency virus-seropositive patients'. Together they form a unique fingerprint.

Cite this