Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

O. M. Wolkowitz; D. Pickar; A. R. Doran; A. Breier; J. Tarell; S. M. Paul

doi:10.1176/ajp.143.1.85

Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

O. M. Wolkowitz, D. Pickar, A. R. Doran, A. Breier, J. Tarell, S. M. Paul

Washington University School of Medicine

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Abstract

Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction of discontinuation of alprazolam.

Original language	English
Pages (from-to)	85-87
Number of pages	3
Journal	American Journal of Psychiatry
Volume	143
Issue number	1
DOIs	https://doi.org/10.1176/ajp.143.1.85
State	Published - 1986

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title = "Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia",

abstract = "Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction of discontinuation of alprazolam.",

author = "Wolkowitz, {O. M.} and D. Pickar and Doran, {A. R.} and A. Breier and J. Tarell and Paul, {S. M.}",

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AU - Wolkowitz, O. M.

AU - Pickar, D.

AU - Doran, A. R.

AU - Breier, A.

AU - Tarell, J.

AU - Paul, S. M.

PY - 1986

Y1 - 1986

N2 - Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction of discontinuation of alprazolam.

AB - Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction of discontinuation of alprazolam.

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U2 - 10.1176/ajp.143.1.85

DO - 10.1176/ajp.143.1.85

M3 - Article

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AN - SCOPUS:0022631745

SN - 0002-953X

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SP - 85

EP - 87

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 1

ER -

Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

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