Column-switching HPLC for the analysis of plasma in PET imaging studies

John Hilton, Fuji Yokoi, Robert F. Dannals, Hayden T. Ravert, Zsolt Szabo, Dean F. Wong

Research output: Contribution to journalArticlepeer-review

179 Scopus citations


A column-switch high performance liquid chromatography method for the analysis of 4 mL of plasma is described with six examples of chromatography of [11C]-labeled positron-emission tomography imaging agents. Complete extraction of all but the most polar metabolites by the reverse phase capture column is achieved by disruption of plasma protein binding by 8 M urea. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)627-630
Number of pages4
JournalNuclear Medicine and Biology
Issue number6
StatePublished - 2000


  • Column-switch
  • HPLC
  • PET
  • Plasma


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