Collision-induced dissociations of deprotonated dipeptide methyl esters containing H, alkyl or benzyl α side-chains

Adrian M. Bradford, Russell J. Waugh, John H. Bowie, David L. Vollmer, Michael L. Gross

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The mass spectra of (M - H)- ions derived from dipeptide methyl esters are not as useful from an analytical viewpoint as those of the underivatised peptides in that they lack the characteristic backbone cleavage which provides the primary sequencing data. Instead, major fragmentation occurs through the ester group, viz. competitive losses of MeOH and HCO2Me are noted. Specific fragmentations differentiate between dipeptide methyl esters containing C- and N-terminal Phe. Deuterium labelling and product ion studies have aided this investigation.

Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalInternational Journal of Mass Spectrometry and Ion Processes
Volume136
Issue number2-3
DOIs
StatePublished - Sep 22 1994

Keywords

  • Collision-induced dissociations
  • Dipeptide methyl esters

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