Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

Michael D. Fox; Abraham Z. Snyder; Jeffrey M. Zacks; Marcus E. Raichle

doi:10.1038/nn1616

Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

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Abstract

Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Nature neuroscience
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/nn1616
State	Published - Jan 2006

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title = "Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses",

abstract = "Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.",

author = "Fox, \{Michael D.\} and Snyder, \{Abraham Z.\} and Zacks, \{Jeffrey M.\} and Raichle, \{Marcus E.\}",

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AB - Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.

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Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

Abstract

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