Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

Michael D. Fox, Abraham Z. Snyder, Jeffrey M. Zacks, Marcus E. Raichle

Research output: Contribution to journalArticle

468 Scopus citations

Abstract

Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalNature neuroscience
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2006

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