Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia

Beth E. Snitz, Lisa A. Weissfeld, Oscar L. Lopez, Lewis H. Kuller, Judith Saxton, Dilrukshika M. Singhabahu, William E. Klunk, Chester A. Mathis, Julie C. Price, Diane G. Ives, Ann D. Cohen, Eric McDade, Steven T. DeKosky

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Abstract

Objective: To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging. Methods: A total of 194 participants (mean age 85.5 years, range 82-95) who completed the Ginkgo Evaluation of Memory Study (GEMS) and remained dementia-free subsequently completed Pittsburgh compound B-PET imaging. We examined cross-sectional associations between Aβ status and performance on a broad neuropsychological test battery completed at GEMS entry 7-9 years prior to neuroimaging. We also longitudinally examined cognition over annual evaluations using linear mixed models. Results: At GEMS screening (2000-2002), participants who were Aβ-positive in 2009 had lower performance on the Stroop test (p < 0.01) and Raven's Progressive Matrices (p = 0.05), with trend level difference for Block Design (p = 0.07). Longitudinal analyses showed significant slope differences for immediate and delayed recall of the Rey-Osterrieth figure, semantic fluency, and Trail-Making Test parts A and B, indicating greater performance decline prior to neuroimaging for Aβ-positive relative to Aβ-negative participants (ps < 0.05). Conclusions: Highly prevalent Aβ deposition in oldest-older adults is associated with cognitive decline in visual memory, semantic fluency, and psychomotor speed beginning 7-9 years prior to neuroimaging. Mean differences in nonmemory domains, primarily executive functions, between Aβ-status groups may be detectable 7-9 years before neuroimaging.

Original languageEnglish
Pages (from-to)1378-1384
Number of pages7
JournalNeurology
Volume80
Issue number15
DOIs
StatePublished - Apr 9 2013
Externally publishedYes

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    Snitz, B. E., Weissfeld, L. A., Lopez, O. L., Kuller, L. H., Saxton, J., Singhabahu, D. M., Klunk, W. E., Mathis, C. A., Price, J. C., Ives, D. G., Cohen, A. D., McDade, E., & DeKosky, S. T. (2013). Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia. Neurology, 80(15), 1378-1384. https://doi.org/10.1212/WNL.0b013e31828c2fc8