@article{1d56acfa27e34e48874c01836b463392,
title = "Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life",
abstract = "We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.",
keywords = "Amyloid, PET imaging, cohort study, education, epidemiology, human",
author = "Rawlings, {Andreea M.} and Sharrett, {A. Richey} and Mosley, {Thomas H.} and Wong, {Dean F.} and Knopman, {David S.} and Gottesman, {Rebecca F.}",
note = "Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I, HHSN268201700005I). Neurocognitive data is collected by U01 HL096812, HL096814, HL096899, HL096902, HL096917 with previous brain MRI examinations funded by R01-HL70825. AMR was supported by NIH/NHLBI grant T32 HL007024. This work was supported by NIH/NIA grant K24AG052573 to RG. The authors thank the staff and participants of the ARIC study for their important contributions. The ARIC-PET study is funded by the National Institute on Aging (R01AG040282). Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201700001I, HHSN268201700002I, HH SN268201700003I, HHSN268201700004I, HHSN 268201700005I). Neurocognitive data is collected by U01 HL096812, HL096814, HL096899, HL096902, HL096917 with previous brain MRI examinations funded by R01-HL70825. AMR was supported by NIH/NHLBI grant T32 HL007024. This work was Publisher Copyright: {\textcopyright} 2019 - IOS Press and the authors. All rights reserved.",
year = "2019",
doi = "10.3233/JAD-180785",
language = "English",
volume = "68",
pages = "517--521",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
number = "2",
}