TY - JOUR
T1 - Cognitive behavior therapy for depression in type 2 diabetes mellitus. A randomized, controlled trial
AU - Lustman, Patrick J.
AU - Griffith, Linda S.
AU - Freedland, Kenneth E.
AU - Kissel, Sarah S.
AU - Clouse, Ray E.
PY - 1998/10/15
Y1 - 1998/10/15
N2 - Background: Psychotherapy is the principal nonpharmacologic method for the management of depression, but its usefulness for depressed patients with diabetes remains unknown. Objective: To assess the efficacy of cognitive behavior therapy (CBT) for depression in patients with diabetes. Design: Randomized, controlled trial. Setting: Referral-based academic medical center. Patients: 51 patients with type 2 diabetes and major depression. Intervention: Patients were assigned either to a group that received 10 weeks of individual CBT or to a control group that received no specific antidepressant treatment. All patients participated in a diabetes education program to control for the effects of supportive attention and the possible influence of enhanced diabetes control on mood. Measurements: Degree of depression was measured by using the Beck Depression Inventory; glycemic control was measured by using glycosylated hemoglobin levels. Outcomes were assessed immediately after treatment and 6 months after treatment. Results: The percentage of patients achieving remission of depression (Beck Depression Inventory score ≤ 9) was greater in the CRT group than in the control group: posttreatment, 85.0% of patients in the CBT group (17 of 20) compared with 27.3% of controls (6 of 22) achieved remission (difference, 57.7 percentage points [95% CI, 33 to 82 percentage points]) (P < 0.001); at follow-up, 70.0% of patients in the CBT group (14 of 20) compared with 33.3% of controls (7 of 21) achieved remission (difference, 36.7 percentage points [CI, 9 to 65 percentage points]) (P = 0.03). Post-treatment glycosylated hemoglobin levels were not different in the two groups, but follow-up mean glycosylated hemoglobin levels were significantly better in the CBT group than in the control group (9.5% compared with 10.9%; P = 0.03). Conclusions: The combination of CBT and supportive diabetes education is an effective nonpharmacologic treatment for major depression in patients with type 2 diabetes. It may also be associated with improved glycemic control.
AB - Background: Psychotherapy is the principal nonpharmacologic method for the management of depression, but its usefulness for depressed patients with diabetes remains unknown. Objective: To assess the efficacy of cognitive behavior therapy (CBT) for depression in patients with diabetes. Design: Randomized, controlled trial. Setting: Referral-based academic medical center. Patients: 51 patients with type 2 diabetes and major depression. Intervention: Patients were assigned either to a group that received 10 weeks of individual CBT or to a control group that received no specific antidepressant treatment. All patients participated in a diabetes education program to control for the effects of supportive attention and the possible influence of enhanced diabetes control on mood. Measurements: Degree of depression was measured by using the Beck Depression Inventory; glycemic control was measured by using glycosylated hemoglobin levels. Outcomes were assessed immediately after treatment and 6 months after treatment. Results: The percentage of patients achieving remission of depression (Beck Depression Inventory score ≤ 9) was greater in the CRT group than in the control group: posttreatment, 85.0% of patients in the CBT group (17 of 20) compared with 27.3% of controls (6 of 22) achieved remission (difference, 57.7 percentage points [95% CI, 33 to 82 percentage points]) (P < 0.001); at follow-up, 70.0% of patients in the CBT group (14 of 20) compared with 33.3% of controls (7 of 21) achieved remission (difference, 36.7 percentage points [CI, 9 to 65 percentage points]) (P = 0.03). Post-treatment glycosylated hemoglobin levels were not different in the two groups, but follow-up mean glycosylated hemoglobin levels were significantly better in the CBT group than in the control group (9.5% compared with 10.9%; P = 0.03). Conclusions: The combination of CBT and supportive diabetes education is an effective nonpharmacologic treatment for major depression in patients with type 2 diabetes. It may also be associated with improved glycemic control.
UR - http://www.scopus.com/inward/record.url?scp=0032532409&partnerID=8YFLogxK
U2 - 10.7326/0003-4819-129-8-199810150-00005
DO - 10.7326/0003-4819-129-8-199810150-00005
M3 - Article
C2 - 9786808
AN - SCOPUS:0032532409
SN - 0003-4819
VL - 129
SP - 613
EP - 621
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 8
ER -