Coffee, caffeine, and cardiovascular disease

To the Editor: Grobbee et al. (Oct. 11 issue)¹ claim that their data do not support the hypothesis that coffee consumption increases the risk of coronary heart disease. They fail to make the distinction between evidence against the hypothesis and a lack of information. Two studies have documented that men drinking 5 or more cups of coffee a day had an increase in the risk of myocardial infarction,² or of coronary heart disease,³ of about twofold; it approximated threefold among those drinking 10 or more cups a day.² Grobbee et al. had insufficient data to assess the effect of 5.