TY - JOUR
T1 - Coexistence of inflammatory hepatocellular adenomas with HNF1α-inactivated adenomas
T2 - Is there an association?
AU - Castain, Claire
AU - Sempoux, Christine
AU - Brunt, Elizabeth M.
AU - Causse, Olivier
AU - Heitzmann, Anne
AU - Hernandez-Prera, Juan C.
AU - Le Bail, Brigitte
AU - Schirmacher, Peter
AU - Thung, Swan N.
AU - Balabaud, Charles
AU - Bioulac-Sage, Paulette
PY - 2014/5
Y1 - 2014/5
N2 - Aims: To report the coexistence of inflammatory hepatocellular adenoma (IHCA) and HNF1α-inactivated HCA (H-HCA) in cases from a multicentre study. Methods and results: We report nine cases with the coexistence of IHCA and H-HCA; eight occurred in women, and one in a man. The numbers of nodules and the sizes of the largest and smallest HCAs were variable. In one case, the nodules of the two different subtypes were discovered at different times. In all women, HCAs were histologically typical, regardless of their subtype, whereas H-HCA in the man differed histologically from classic H-HCA. Conclusions: These cases suggest that a predisposition to develop multiple adenomas, hypothetically caused by a 'benign tumorigenic field effect', although common to all HCAs, may result in different genotypes and phenotypes. Although this is rare, it is expected that more cases with the coexistence of different genotypes will emerge, owing to progress in the use of specific immunohistochemical approaches.
AB - Aims: To report the coexistence of inflammatory hepatocellular adenoma (IHCA) and HNF1α-inactivated HCA (H-HCA) in cases from a multicentre study. Methods and results: We report nine cases with the coexistence of IHCA and H-HCA; eight occurred in women, and one in a man. The numbers of nodules and the sizes of the largest and smallest HCAs were variable. In one case, the nodules of the two different subtypes were discovered at different times. In all women, HCAs were histologically typical, regardless of their subtype, whereas H-HCA in the man differed histologically from classic H-HCA. Conclusions: These cases suggest that a predisposition to develop multiple adenomas, hypothetically caused by a 'benign tumorigenic field effect', although common to all HCAs, may result in different genotypes and phenotypes. Although this is rare, it is expected that more cases with the coexistence of different genotypes will emerge, owing to progress in the use of specific immunohistochemical approaches.
KW - Hepatocellular adenoma subtypes
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=84898058749&partnerID=8YFLogxK
U2 - 10.1111/his.12326
DO - 10.1111/his.12326
M3 - Article
C2 - 24236804
AN - SCOPUS:84898058749
SN - 0309-0167
VL - 64
SP - 890
EP - 895
JO - Histopathology
JF - Histopathology
IS - 6
ER -