21 Scopus citations

Abstract

BackgroundPseudoprogression (PsP) occurs at a higher rate in glioblastoma multiforme with a methylated MGMT promoter - a subset with increased sensitivity to chemoradiotherapy and better overall prognosis. In oligodendroglioma (OG) and oligoastrocytoma (OA), presence of 1p/19q codeletions is highly predictive of response to treatment and is often associated with the methylated MGMT promoter; hence, this study queries whether the presence of 1p/19q codeletions in OG/OA correlates with a higher rate of PsP following therapy.MethodsA retrospective analysis was performed on all OG/OA in a database of patients with brain tumors who underwent resection of their tumor since 1998. Eighty-eight cases (37 with and 51 without 1p/19q codeletions) met inclusion criteria, and their patient data were analyzed to determine whether the presence of 1p/19q codeletions was associated with PsP and survival.ResultsOG/OA (World Health Organization grades II and III) with 1p/19q codeletions had a significantly improved survival (P =. 041). Multivariate analysis found that PsP occurred less frequently in OG/OA with 1p/19q codeletions compared with tumors without codeletions (odds ratio, 0.047; 95% confidence interval, 0.005-0.426; P =. 0066). The rate of PsP was 19% for the entire cohort, 31% for tumors without codeletions, and 3% for tumors with codeletions. When early posttreatment contrast enhancement developed in tumors with 1p/19q codeletions, it occurred exclusively in tumors that were histologically OA and not OG. ConclusionCodeletions of 1p/19q are a marker of good prognosis but are unexpectedly associated with a lower likelihood of PsP. PsP does not correlate with sensitivity to treatment and improved survival in OG/OA.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalNeuro-oncology
Volume16
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • 1p/19q codeletions
  • oligoastrocytoma
  • oligodendroglioma
  • p53.
  • pseudoprogression

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