Coded aperture x-ray diffraction imaging with transmission computed tomography side-information

Ikenna Odinaka, Joel A. Greenberg, Yan Kaganovsky, Andrew Holmgren, Mehadi Hassan, David G. Politte, Joseph A. O'Sullivan, Lawrence Carin, David J. Brady

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


Coded aperture X-ray diffraction (coherent scatter spectral) imaging provides fast and dose-efficient measurements of the molecular structure of an object. The information provided is spatially-dependent and material-specific, and can be utilized in medical applications requiring material discrimination, such as tumor imaging. However, current coded aperture coherent scatter spectral imaging system assume a uniformly or weakly attenuating object, and are plagued by image degradation due to non-uniform self-attenuation. We propose accounting for such non-uniformities in the self-attenuation by utilizing an X-ray computed tomography (CT) image (reconstructed attenuation map). In particular, we present an iterative algorithm for coherent scatter spectral image reconstruction, which incorporates the attenuation map, at different stages, resulting in more accurate coherent scatter spectral images in comparison to their uncorrected counterpart. The algorithm is based on a spectrally grouped edge-preserving regularizer, where the neighborhood edge weights are determined by spatial distances and attenuation values.

Original languageEnglish
Title of host publicationMedical Imaging 2016
Subtitle of host publicationPhysics of Medical Imaging
EditorsDespina Kontos, Joseph Y. Lo, Thomas G. Flohr
ISBN (Electronic)9781510600188
StatePublished - 2016
EventMedical Imaging 2016: Physics of Medical Imaging - San Diego, United States
Duration: Feb 28 2016Mar 2 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2016: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego


  • X-ray diffraction imaging
  • attenuation correction
  • coded aperture x-ray imaging
  • coherent scatter and attenuation fusion
  • coherent scatter imaging
  • group edge-preserving regularizer
  • material identification
  • x-ray CT imaging


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