Co-survival of the fittest few: Mosaic amplification of receptor tyrosine kinases in glioblastoma

Feng Chen; Li Ding

doi:10.1186/gb-2012-13-1-141

Co-survival of the fittest few: Mosaic amplification of receptor tyrosine kinases in glioblastoma

Feng Chen
, Li Ding

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Mosaic amplification of receptor tyrosine kinases in glioblastoma suggests that tumor cells with different progression driver mutations may coevolve rather than compete during clonal evolution.

Original language	English
Article number	141
Journal	Genome biology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/gb-2012-13-1-141
State	Published - Jan 30 2012

Keywords

Clonal evolution
Glioblastoma
Mosaic amplification
Progression driver mutations
Receptor tyrosine kinases
Tumor heterogeneity

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10.1186/gb-2012-13-1-141

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title = "Co-survival of the fittest few: Mosaic amplification of receptor tyrosine kinases in glioblastoma",

abstract = "Mosaic amplification of receptor tyrosine kinases in glioblastoma suggests that tumor cells with different progression driver mutations may coevolve rather than compete during clonal evolution.",

keywords = "Clonal evolution, Glioblastoma, Mosaic amplification, Progression driver mutations, Receptor tyrosine kinases, Tumor heterogeneity",

author = "Feng Chen and Li Ding",

note = "Funding Information: The authors are supported by grants from the NIH (R01DK081592, R01DK087960, U01HG005209, U54HG003079, and R01HG005690). We thank Timothy J Ley for constructive comments on the manuscript.",

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T2 - Mosaic amplification of receptor tyrosine kinases in glioblastoma

AU - Chen, Feng

AU - Ding, Li

N1 - Funding Information: The authors are supported by grants from the NIH (R01DK081592, R01DK087960, U01HG005209, U54HG003079, and R01HG005690). We thank Timothy J Ley for constructive comments on the manuscript.

PY - 2012/1/30

Y1 - 2012/1/30

N2 - Mosaic amplification of receptor tyrosine kinases in glioblastoma suggests that tumor cells with different progression driver mutations may coevolve rather than compete during clonal evolution.

AB - Mosaic amplification of receptor tyrosine kinases in glioblastoma suggests that tumor cells with different progression driver mutations may coevolve rather than compete during clonal evolution.

KW - Clonal evolution

KW - Glioblastoma

KW - Mosaic amplification

KW - Progression driver mutations

KW - Receptor tyrosine kinases

KW - Tumor heterogeneity

UR - https://www.scopus.com/pages/publications/84856103316

U2 - 10.1186/gb-2012-13-1-141

DO - 10.1186/gb-2012-13-1-141

M3 - Comment/debate

C2 - 22289423

AN - SCOPUS:84856103316

SN - 1474-7596

VL - 13

JO - Genome biology

JF - Genome biology

IS - 1

M1 - 141

ER -

Co-survival of the fittest few: Mosaic amplification of receptor tyrosine kinases in glioblastoma

Abstract

Keywords

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