TY - GEN
T1 - Co-registered photoacoustic and ultrasound real-time imaging of colorectal cancer
T2 - Photons Plus Ultrasound: Imaging and Sensing 2019
AU - Yang, Guang
AU - Amidi, Eghbal
AU - Chapman, William
AU - Nandy, Sreyankar
AU - Mostafa, Atahar
AU - Abdelal, Heba
AU - Alipour, Zahra
AU - Chatterjee, Deyali
AU - Mutch, Matthew
AU - Zhu, Quing
N1 - Funding Information:
Acknowledgments: Research in this publication was partially funded by R01CA151570 and R01EB002136, and supported by the Washington University School of Medicine Surgical Oncology Basic Science and Translational Research Training Program grant T32CA009621 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2019
Y1 - 2019
N2 - Colorectal cancer is the second most common malignancy diagnosed globally. Critical need exists for imaging and diagnosis of rectal tumors for both staging and therapeutic response evaluations. We have conducted a pilot study to image and characterize colorectal masses using a real-time co-registered photoacoustic (PAT) and ultrasound (US) system. A total of 8 tissue samples including pre- and post-treatment colorectal cancer, polyps have studied. Four different wavelengths (730, 780, 800, 830 nm) were used to illuminate the sample and a scanning stage was used to scan a large area and obtain a sequence of B-scans. For the pre-treatment colorectal cancer, photoacoustic images have shown significantly higher vascular level than neighbor benign regions of the same sample. The pre-treatment colorectal cancer PAT signal level is also higher than polyps and post-treatment colorectal cancer. Additionally, the quantitative features extracted from PAT and US power spectrum such as spectral slope, mid-band fit and zero MHz intercept have shown statistical significance between pre-treatment colorectal cancer and other 3 categories using t-test. Our initial results have demonstrated that PAT/US has a great potential to reveal tumor angiogenesis development or residual tumors after treatment.
AB - Colorectal cancer is the second most common malignancy diagnosed globally. Critical need exists for imaging and diagnosis of rectal tumors for both staging and therapeutic response evaluations. We have conducted a pilot study to image and characterize colorectal masses using a real-time co-registered photoacoustic (PAT) and ultrasound (US) system. A total of 8 tissue samples including pre- and post-treatment colorectal cancer, polyps have studied. Four different wavelengths (730, 780, 800, 830 nm) were used to illuminate the sample and a scanning stage was used to scan a large area and obtain a sequence of B-scans. For the pre-treatment colorectal cancer, photoacoustic images have shown significantly higher vascular level than neighbor benign regions of the same sample. The pre-treatment colorectal cancer PAT signal level is also higher than polyps and post-treatment colorectal cancer. Additionally, the quantitative features extracted from PAT and US power spectrum such as spectral slope, mid-band fit and zero MHz intercept have shown statistical significance between pre-treatment colorectal cancer and other 3 categories using t-test. Our initial results have demonstrated that PAT/US has a great potential to reveal tumor angiogenesis development or residual tumors after treatment.
KW - Human colorectal cancer
KW - Photoacoustic and ultrasound imaging
KW - Quantitative analysis
UR - http://www.scopus.com/inward/record.url?scp=85065415444&partnerID=8YFLogxK
U2 - 10.1117/12.2507638
DO - 10.1117/12.2507638
M3 - Conference contribution
AN - SCOPUS:85065415444
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
Y2 - 3 February 2019 through 6 February 2019
ER -