Co-detection: Ultra-reliable nanoparticle-based electrical detection of biomolecules in the presence of large background interference

Yang Liu, Ming Gu, Evangelyn C. Alocilja, Shantanu Chakrabartty

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

An ultra-reliable technique for detecting trace quantities of biomolecules is reported. The technique called " co-detection" exploits the non-linear redundancy amongst synthetically patterned biomolecular logic circuits for deciphering the presence or absence of target biomolecules in a sample. In this paper, we verify the " co-detection" principle on gold-nanoparticle-based conductimetric soft-logic circuits which use a silver-enhancement technique for signal amplification. Using co-detection, we have been able to demonstrate a great improvement in the reliability of detecting mouse IgG at concentration levels that are 105 lower than the concentration of rabbit IgG which serves as background interference.

Original languageEnglish
Pages (from-to)1087-1092
Number of pages6
JournalBiosensors and Bioelectronics
Volume26
Issue number3
DOIs
StatePublished - Nov 15 2010

Keywords

  • Biomolecular circuits
  • Biomolecules
  • Biosensor
  • Co-detection
  • Electrical detection
  • Forward error-correction biosensor

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