TY - JOUR
T1 - CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 2
T2 - Discussion of neuro-immune reconstitution inflammatory syndrome with and without other pathogens
AU - Post, M. J.D.
AU - Thurnher, M. M.
AU - Clifford, D. B.
AU - Nath, A.
AU - Gonzalez, R. G.
AU - Gupta, R. K.
AU - Post, K. K.
PY - 2013/7
Y1 - 2013/7
N2 - While the previous review of CNS-IRIS in the HIV-infected patient on highly active antiretroviral therapy (Part 1) dealt with an overview of the biology, pathology, and neurologic presentation of this condition and a discussion of the atypical imaging findings in PML-IRIS and cryptococcal meningitis-IRIS due to the robust inflammatory response, the current review (Part 2) discusses the imaging findings in other commonly encountered organisms seen in association with CNS-IRIS, namely, VZV, CMV, HIV, Candida organisms, Mycobacterium tuberculosis, and Toxoplasma gondii. Also described is the imaging appearance of CNS-IRIS when not associated with a particular organism. Recognition of these imaging findings will give credence to the diagnosis of CNS-IRIS and will allow the clinician to institute changes in medical management, if necessary, so that immune reconstitution and improved patient outcome can occur with time.
AB - While the previous review of CNS-IRIS in the HIV-infected patient on highly active antiretroviral therapy (Part 1) dealt with an overview of the biology, pathology, and neurologic presentation of this condition and a discussion of the atypical imaging findings in PML-IRIS and cryptococcal meningitis-IRIS due to the robust inflammatory response, the current review (Part 2) discusses the imaging findings in other commonly encountered organisms seen in association with CNS-IRIS, namely, VZV, CMV, HIV, Candida organisms, Mycobacterium tuberculosis, and Toxoplasma gondii. Also described is the imaging appearance of CNS-IRIS when not associated with a particular organism. Recognition of these imaging findings will give credence to the diagnosis of CNS-IRIS and will allow the clinician to institute changes in medical management, if necessary, so that immune reconstitution and improved patient outcome can occur with time.
UR - http://www.scopus.com/inward/record.url?scp=84880836291&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A3184
DO - 10.3174/ajnr.A3184
M3 - Review article
C2 - 22790252
AN - SCOPUS:84880836291
SN - 0195-6108
VL - 34
SP - 1308
EP - 1318
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 7
ER -