The dissection of genetic resistance to murine cytomegalovirus infection in inbred laboratory mouse strains led to the identification of a natural killer cell activation receptor that recognizes a virus-encoded protein. Herein, we summarize the genetic approach and findings that have provided novel insights into innate immune control of virus infections.
|Title of host publication||Immunology, Phenotype First|
|Subtitle of host publication||How Mutations Have Established New Principles and Pathways in Immunology|
|Number of pages||22|
|State||Published - 2008|
|Name||Current Topics in Microbiology and Immunology|