TY - JOUR
T1 - Clostridium difficile Infection in the Intensive Care Unit
AU - Riddle, David J.
AU - Dubberke, Erik R.
N1 - Funding Information:
This work was supported by grant T32 HD007507 from the NICHD and 1 UL1 RR024992-01 (PI: Polonsky); 1 KL2 RR024994-01 (PI: Fraser) from the NCRR.
PY - 2009/9
Y1 - 2009/9
N2 - Clostridium difficile infection (CDI) is becoming more common worldwide. The morbidity and mortality associated with C difficile is also increasing at an alarming rate. Critically ill patients are at particularly high risk for CDI because of the prevalence of multiple risk factors in this patient population. Treatment of C difficile continues to be a difficult problem in patients with severe or recurrent disease. This article seeks to provide a broad understanding of CDI in the intensive care unit, with special emphasis on risk factor identification, treatment options, and disease prevention.
AB - Clostridium difficile infection (CDI) is becoming more common worldwide. The morbidity and mortality associated with C difficile is also increasing at an alarming rate. Critically ill patients are at particularly high risk for CDI because of the prevalence of multiple risk factors in this patient population. Treatment of C difficile continues to be a difficult problem in patients with severe or recurrent disease. This article seeks to provide a broad understanding of CDI in the intensive care unit, with special emphasis on risk factor identification, treatment options, and disease prevention.
KW - Clostridium difficile
KW - Critical care
KW - Intensive care
KW - Nosocomial infection
KW - Pseudomembranous colitis
UR - http://www.scopus.com/inward/record.url?scp=68249091971&partnerID=8YFLogxK
U2 - 10.1016/j.idc.2009.04.011
DO - 10.1016/j.idc.2009.04.011
M3 - Review article
C2 - 19665092
AN - SCOPUS:68249091971
SN - 0891-5520
VL - 23
SP - 727
EP - 743
JO - Infectious disease clinics of North America
JF - Infectious disease clinics of North America
IS - 3
ER -