Clostridium difficile Infection in the Intensive Care Unit

David J. Riddle, Erik R. Dubberke

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Clostridium difficile infection (CDI) is becoming more common worldwide. The morbidity and mortality associated with C difficile is also increasing at an alarming rate. Critically ill patients are at particularly high risk for CDI because of the prevalence of multiple risk factors in this patient population. Treatment of C difficile continues to be a difficult problem in patients with severe or recurrent disease. This article seeks to provide a broad understanding of CDI in the intensive care unit, with special emphasis on risk factor identification, treatment options, and disease prevention.

Original languageEnglish
Pages (from-to)727-743
Number of pages17
JournalInfectious disease clinics of North America
Issue number3
StatePublished - Sep 2009


  • Clostridium difficile
  • Critical care
  • Intensive care
  • Nosocomial infection
  • Pseudomembranous colitis


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