Clostridium difficile Colitis

Philip A. Efron, John E. Mazuski

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Its effects are mediated by C difficile toxins A and B. Recent outbreaks of severe colitis have been associated with a new strain of the bacterium that produces large amounts of the toxins. Although oral metronidazole and oral vancomycin can be used to treat C difficile-associated disease, intraluminal vancomycin is preferable for more severe C difficile colitis. Early surgical intervention can improve outcomes with fulminant colitis, although overall mortality remains high.

Original languageEnglish
Pages (from-to)483-500
Number of pages18
JournalSurgical Clinics of North America
Issue number2
StatePublished - Apr 2009


  • Clostridium difficile
  • Colitis
  • Diarrhea
  • Infection


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