Close distal margin is associated with locoregional rectal cancer recurrence: A multicenter study

Christopher J. Varlamos, Brandy Sinco, Inga Van Weiren, Scott Regenbogen, Adriana C. Gamboa, Matthew Silviera, Sherif R.Z. Abdel-Misih, Alexander T. Hawkins, Glen Balch, Samantha Hendren

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background and Objectives: The importance of the radial margin for rectal cancer resection is well understood. However, surgeons have deemphasized the distal margin, accepting very close distal margins to perform sphincter-preserving surgery. We hypothesized that distal margins < 1 cm would be an independent risk factor for locoregional recurrence. The objective was to determine whether close distal margins are associated with increased locoregional recurrence risk. Methods: This was a multi-institutional retrospective cohort study conducted at six academic medical centers including patients who received low anterior resection surgery for primary rectal cancer between 2007 and 2018. Results: Of 556 low anterior resection patients, the rate of close distal margin was 12.8% (n = 71), and the locoregional recurrence rate was 5.0% (n = 28). The locoregional recurrence rate for close distal margin cases was 9.9% (n = 7) compared to 4.3% (n = 21) for distal margins ≥1.0 cm. In multivariable analysis, the only factor significantly associated with locoregional recurrence was close distal margin (adjusted odds ratio: 2.80, confidence interval: 1.08–7.25, p = 0.035). Conclusions: Rectal cancer patients with close distal margins (<1 cm) following low anterior resection had a significantly higher risk for locoregional recurrence. Therefore, the decision to perform low anterior resection with margins < 1 cm should be taken with caution.

Original languageEnglish
Pages (from-to)1106-1113
Number of pages8
JournalJournal of surgical oncology
Issue number7
StatePublished - Dec 2023


  • distal margin
  • locoregional cancer recurrence
  • rectal cancer


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