Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion

Lydia Aguilar-Bryan; Colin G. Nichols; Sérgio W. Wechsler; John P. Clement IV; A. E. Boyd; Gabriela González; Haydée Herrera-Sosa; Kimberly Nguy; Joseph Bryan; Daniel A. Nelson

Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion

Lydia Aguilar-Bryan, Colin G. Nichols, Sérgio W. Wechsler, John P. Clement IV, A. E. Boyd, Gabriela González, Haydée Herrera-Sosa, Kimberly Nguy, Joseph Bryan, Daniel A. Nelson

Research output: Contribution to journal › Article › peer-review

1325 Scopus citations

Abstract

Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic P cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K(ATP)) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect K(ATP) channel activity, and thereby modulate insulin release.

Original language	English
Pages (from-to)	423-426
Number of pages	4
Journal	Science
Volume	268
Issue number	5209
State	Published - Apr 21 1995

Cite this

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title = "Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion",

abstract = "Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic P cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K(ATP)) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect K(ATP) channel activity, and thereby modulate insulin release.",

author = "Lydia Aguilar-Bryan and Nichols, {Colin G.} and Wechsler, {S{\'e}rgio W.} and {Clement IV}, {John P.} and Boyd, {A. E.} and Gabriela Gonz{\'a}lez and Hayd{\'e}e Herrera-Sosa and Kimberly Nguy and Joseph Bryan and Nelson, {Daniel A.}",

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T2 - A regulator of insulin secretion

AU - Aguilar-Bryan, Lydia

AU - Nichols, Colin G.

AU - Wechsler, Sérgio W.

AU - Clement IV, John P.

AU - Boyd, A. E.

AU - González, Gabriela

AU - Herrera-Sosa, Haydée

AU - Nguy, Kimberly

AU - Bryan, Joseph

AU - Nelson, Daniel A.

PY - 1995/4/21

Y1 - 1995/4/21

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AB - Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic P cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K(ATP)) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect K(ATP) channel activity, and thereby modulate insulin release.

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VL - 268

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EP - 426

JO - Science

JF - Science

IS - 5209

ER -

Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion

Abstract

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