Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion

Lydia Aguilar-Bryan, Colin G. Nichols, Sérgio W. Wechsler, John P. Clement IV, A. E. Boyd, Gabriela González, Haydée Herrera-Sosa, Kimberly Nguy, Joseph Bryan, Daniel A. Nelson

Research output: Contribution to journalArticle

1222 Scopus citations

Abstract

Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic β cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K ATP) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release.

Original languageEnglish
Pages (from-to)423-426
Number of pages4
JournalScience
Volume268
Issue number5209
DOIs
StatePublished - Jan 1 1995

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    Aguilar-Bryan, L., Nichols, C. G., Wechsler, S. W., Clement IV, J. P., Boyd, A. E., González, G., Herrera-Sosa, H., Nguy, K., Bryan, J., & Nelson, D. A. (1995). Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion. Science, 268(5209), 423-426. https://doi.org/10.1126/science.7716547