Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways

Jacqueline Samaridis, Marco Colonna

Research output: Contribution to journalArticlepeer-review

237 Scopus citations

Abstract

We have identified two novel human cDNA encoding transmembrane proteins of the immunoglobulin superfamily (IgSF). The two cDNA, called immunoglobulin-like transcripts 1 and 2 (ILT1 and ILT2), are expressed in myeloid and lymphoid cells and are homologous to bovine Fcγ2R, human killer cell inhibitory receptors (KIR), human FcαR, and mouse gp49. Furthermore, ILT1 and ILT2 are encoded on chromosome 19, as are FcαR and KIR. While the ILT1 and ILT2 extracellular domains are homologous, the transmembrane and cytoplasmic domains differ substantially. ILT1 has an arginine within the transmembrane region, followed by a short cytoplasmic tail, similar to human FcαRI and bovine Fcγ2R. ILT2 has a long cytoplasmic tail, which contains two YxxV and two YxxL pairs similar to the immunoreceptor tyrosine-based inhibitory motifs in KIR that are known to bind the phosphotyrosine phosphatase SHP-1. These cytoplasmic features suggest that ILT1 and ILT2 may mediate novel transmembrane signals by which myeloid and lymphoid cell responses can be either activated or inhibited.

Original languageEnglish
Pages (from-to)660-665
Number of pages6
JournalEuropean Journal of Immunology
Volume27
Issue number3
DOIs
StatePublished - Mar 20 1997
Externally publishedYes

Keywords

  • B cell
  • Fc receptor
  • Immunoglobulin superfamily
  • Killer cell inhibitory receptors
  • Myeloid cell

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