Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes

Béatrice Plougastel, John Trowsdale

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51 Scopus citations

Abstract

The NKG2 family of genes encodes at least four different type II transmembrane molecules (NKG2-A, NKG2-B, NKG2-C and NKG2-E) which contain a C-lectin domain. These proteins have been shown to be covalently associated with CD94, another C-type lectin member. The heterodimers are involved in natural killer cell-mediated recognition of different HLA-allotypes. Here we describe the cloning of a new NKG2-related gene, termed NKG2-F localized 25 kb from NKG2-A as well as its relationship with the previously described NKG2-D cDNA. Despite the similarities with the other NKG2 genes, NKG2-F encodes a putative protein which does not contain any lectin domain. However, a conserved 24-amino acid sequence, present in all members of the NKG2 family, suggests that NKG2-F is also able to form heterodimers with CD94.

Original languageEnglish
Pages (from-to)2835-2839
Number of pages5
JournalEuropean Journal of Immunology
Volume27
Issue number11
DOIs
StatePublished - Nov 1 1997

Keywords

  • CD94
  • NKG2
  • Natural killer cell

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