Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells

Marco Colonna, Jacqueline Samaridis

Research output: Contribution to journalArticle

663 Scopus citations

Abstract

Cytotoxicity by natural killer (NK) cells is inhibited by major histocompatibility complex (MHC) class I molecules on target cells. This inhibition may be mediated by NK receptors with different MHC specificities. A family of four NK-specific complementary DNAs (cDNAs), designated NKATs (NK-associated transcripts), was identified that encoded related transmembrane proteins, characterized by an extracellular region with two or three immunoglobulin-superfamily domains and by a cytoplasmic domain with an unusual antigen receptor activation motif (ARAM). The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalScience
Volume268
Issue number5209
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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