Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

Kevin Ho, Colin G. Nichols, W. Jonathan Lederer, Jonathan Lytton, Peter M. Vassilev, Marie V. Kanazirska, Steven C. Hebert

Research output: Contribution to journalArticlepeer-review

798 Scopus citations

Abstract

A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalNature
Volume362
Issue number6415
DOIs
StatePublished - Jan 1 1993

Fingerprint Dive into the research topics of 'Cloning and expression of an inwardly rectifying ATP-regulated potassium channel'. Together they form a unique fingerprint.

Cite this