Cloning and chromosome localization of the mouse ews gene

Béatrice Plougastel, Marie Geneviève Mattei, Gilles Thomas, Olivier Delattre

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the EWS protein is fused to the DNA binding domain of either FLI1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation product demonstrate 93 and 98% homology with the human EWS cDNA and protein, respectively. The murine Ews locus lies within a conserved synteny segment between human chromosome 22q12 and mouse chromosome 11A1-A3.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
Issue number1
StatePublished - Sep 1994


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