Cloning and chromosome localization of the mouse ews gene

Béatrice Plougastel; Marie Geneviève Mattei; Gilles Thomas; Olivier Delattre

doi:10.1006/geno.1994.1495

Cloning and chromosome localization of the mouse ews gene

Béatrice Plougastel, Marie Geneviève Mattei, Gilles Thomas, Olivier Delattre

Division of Rheumatology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the EWS protein is fused to the DNA binding domain of either FLI1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation product demonstrate 93 and 98% homology with the human EWS cDNA and protein, respectively. The murine Ews locus lies within a conserved synteny segment between human chromosome 22q12 and mouse chromosome 11A1-A3.

Original language	English
Pages (from-to)	278-281
Number of pages	4
Journal	Genomics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1495
State	Published - Sep 1994

Access to Document

10.1006/geno.1994.1495

Cite this

@article{325ce6de8dfa4806abfd21012de9c09f,

title = "Cloning and chromosome localization of the mouse ews gene",

abstract = "The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the EWS protein is fused to the DNA binding domain of either FLI1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation product demonstrate 93 and 98% homology with the human EWS cDNA and protein, respectively. The murine Ews locus lies within a conserved synteny segment between human chromosome 22q12 and mouse chromosome 11A1-A3.",

author = "B{\'e}atrice Plougastel and Mattei, {Marie Genevi{\`e}ve} and Gilles Thomas and Olivier Delattre",

year = "1994",

month = sep,

doi = "10.1006/geno.1994.1495",

language = "English",

volume = "23",

pages = "278--281",

journal = "Genomics",

issn = "0888-7543",

number = "1",

}

TY - JOUR

T1 - Cloning and chromosome localization of the mouse ews gene

AU - Plougastel, Béatrice

AU - Mattei, Marie Geneviève

AU - Thomas, Gilles

AU - Delattre, Olivier

PY - 1994/9

Y1 - 1994/9

N2 - The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the EWS protein is fused to the DNA binding domain of either FLI1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation product demonstrate 93 and 98% homology with the human EWS cDNA and protein, respectively. The murine Ews locus lies within a conserved synteny segment between human chromosome 22q12 and mouse chromosome 11A1-A3.

AB - The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the EWS protein is fused to the DNA binding domain of either FLI1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation product demonstrate 93 and 98% homology with the human EWS cDNA and protein, respectively. The murine Ews locus lies within a conserved synteny segment between human chromosome 22q12 and mouse chromosome 11A1-A3.

UR - http://www.scopus.com/inward/record.url?scp=0028059941&partnerID=8YFLogxK

U2 - 10.1006/geno.1994.1495

DO - 10.1006/geno.1994.1495

M3 - Article

C2 - 7829090

AN - SCOPUS:0028059941

SN - 0888-7543

VL - 23

SP - 278

EP - 281

JO - Genomics

JF - Genomics

IS - 1

ER -

Cloning and chromosome localization of the mouse ews gene

Abstract

Access to Document

Other files and links

Fingerprint

Cite this