Clonal Evolution in Multiple Myeloma

Bita Fakhri, Ravi Vij

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Multiple myeloma (MM) is the second most common hematologic malignancy encountered among patients in the United States. The last decade has seen incremental improvements in the survival of patients with MM. These advances are, to a large extent, attributable to the addition of proteasome inhibitors and immunomodulatory drugs to the armamentarium of treatment options. The adoption of these drug classes was the result of an empiric research paradigm. However, with the application of next generation sequencing technologies, we are now starting to unravel the genomic landscape of MM. It is hoped that this will allow us to better disentangle the biology of the disease and allow for identification of new therapeutic targets. In this article, we review what we have learned to date about the mutational profile, clonal architecture, and evolution of the disease, and discuss the potential clinical implications of these findings.

Original languageEnglish
Pages (from-to)S130-S134
JournalClinical Lymphoma, Myeloma and Leukemia
StatePublished - Aug 1 2016


  • Clonal evolution
  • Genomics
  • Multiple myeloma
  • Mutational landscape
  • Personalized medicine


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